The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Trillions of intestinal bacteria in the human body undergo dynamic transformations in
response to physiological and pathological changes. Alterations in their composition and …

In recent years, several studies described the close relationship between the composition of
gut microbiota and brain functions, highlighting the importance of gut-derived metabolites in …

Alzheimer's disease (AD) is a progressive neurodegenerative disease for which there is a
lack of effective therapeutic drugs. There is great potential for natural products to be used in …

The tetracycline transactivator (tTA) system provides controllable transgene expression
through oral administration of the broad-spectrum antibiotic doxycycline. Antibiotic treatment …

Gut bacteria regulate brain pathology of Alzheimer's disease (AD) patients and animal
models; however, the underlying mechanism remains unclear. In this study, 3-month-old …

Systemic inflammation and neuroinflammation affect the natural course of the sporadic form
of Alzheimer's disease (AD), as supported by epidemiological and preclinical data, and …

Disturbances in the local and peripheral immune systems are closely linked to a wide range
of diseases. In the context of neurodegenerative disorders such as Alzheimer's disease …

With the rapidly aging human population, age-related cognitive decline and dementia are
becoming increasingly prevalent worldwide. Aging is considered the main risk factor for …

The traditional neuron-centric view of the central nervous system (CNS) is shifting toward
recognizing the importance of communication between the neurons and the network of glial …