Virus-like particles: fundamentals and biomedical applications

JL Mejía-Méndez, R Vazquez-Duhalt… - International journal of …, 2022 - mdpi.com
Nanotechnology is a fast-evolving field focused on fabricating nanoscale objects for
industrial, cosmetic, and therapeutic applications. Virus-like particles (VLPs) are self …

EBV-associated diseases: Current therapeutics and emerging technologies

S Chakravorty, B Afzali, M Kazemian - Frontiers in Immunology, 2022 - frontiersin.org
EBV is a prevalent virus, infecting> 90% of the world's population. This is an oncogenic virus
that causes~ 200,000 cancer-related deaths annually. It is, in addition, a significant …

Four ounces can move a thousand pounds: the enormous value of nanomaterials in tumor immunotherapy

Z Chen, Z Yue, K Yang, C Shen… - Advanced …, 2023 - Wiley Online Library
The application of nanomaterials in healthcare has emerged as a promising strategy due to
their unique structural diversity, surface properties, and compositional diversity. In particular …

[HTML][HTML] Integrating immunopeptidome analysis for the design and development of cancer vaccines

S Feola, J Chiaro, V Cerullo - Seminars in immunology, 2023 - Elsevier
The repertoire of naturally presented peptides within the MHC (major histocompatibility
complex) or HLA (human leukocyte antigens) system on the cellular surface of every …

[HTML][HTML] Nanocarrier vaccine therapeutics for global infectious and chronic diseases

FZ Simnani, D Singh, P Patel, A Choudhury, A Sinha… - Materials Today, 2023 - Elsevier
Immunization has the potential to become a viable weapon for the upcoming pandemic and
save millions of lives, while also dramatically lowering the high mortality rate brought on by a …

Yeast-based virus-like particles as an emerging platform for vaccine development and delivery

V Srivastava, KN Nand, A Ahmad, R Kumar - Vaccines, 2023 - mdpi.com
Virus-like particles (VLPs) are empty, nanoscale structures morphologically resembling
viruses. Internal cavity, noninfectious, and particulate nature with a high density of repeating …

Biomimetic nanoparticles for DC vaccination: a versatile approach to boost cancer immunotherapy

L Meng, Z Teng, S Yang, N Wang, YH Guan, X Chen… - Nanoscale, 2023 - pubs.rsc.org
Cancer immunotherapy, which harnesses the immune system to fight cancer, has begun to
make a breakthrough in clinical applications. Dendritic cells (DCs) are the bridge linking …

Virus-based biological systems as next-generation carriers for the therapy of central nervous system diseases

I Nowak, M Madej, J Secemska, R Sarna… - Pharmaceutics, 2023 - mdpi.com
Central nervous system (CNS) diseases are currently a major challenge in medicine. One
reason is the presence of the blood–brain barrier, which is a significant limitation for …

Mechanisms of immune modulation in the tumor microenvironment and implications for targeted therapy

P Czajka-Francuz, MJ Prendes, A Mankan… - Frontiers in …, 2023 - frontiersin.org
The efficacy of cancer therapies is limited to a great extent by immunosuppressive
mechanisms within the tumor microenvironment (TME). Numerous immune escape …

[HTML][HTML] Viral protein-based nanoparticles (part 2): Pharmaceutical applications

R Mellid-Carballal, S Gutierrez-Gutierrez… - European Journal of …, 2023 - Elsevier
ABSTRACT Viral protein nanoparticles (ViP NPs) such as virus-like particles and virosomes
are structures halfway between viruses and synthetic nanoparticles. The biological nature of …