Sex differences and sex steroids in lung health and disease
EA Townsend, VM Miller, YS Prakash - Endocrine reviews, 2012 - academic.oup.com
Sex differences in the biology of different organ systems and the influence of sex hormones
in modulating health and disease are increasingly relevant in clinical and research areas …
in modulating health and disease are increasingly relevant in clinical and research areas …
cAMP regulation of airway smooth muscle function
CK Billington, OO Ojo, RB Penn, S Ito - Pulmonary pharmacology & …, 2013 - Elsevier
Agonists activating β2-adrenoceptors (β2ARs) on airway smooth muscle (ASM) are the drug
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …
of choice for rescue from acute bronchoconstriction in patients with both asthma and chronic …
The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma
Background The role of systemic inflammation in asthma is unclear. The aim of this study
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …
was to compare systemic inflammation in subjects with stable asthma, categorized by airway …
Airway smooth muscle in airway reactivity and remodeling: what have we learned?
YS Prakash - American Journal of Physiology-Lung Cellular …, 2013 - journals.physiology.org
It is now established that airway smooth muscle (ASM) has roles in determining airway
structure and function, well beyond that as the major contractile element. Indeed, changes in …
structure and function, well beyond that as the major contractile element. Indeed, changes in …
The endogenous circadian system worsens asthma at night independent of sleep and other daily behavioral or environmental cycles
FAJL Scheer, MF Hilton, HL Evoniuk… - Proceedings of the …, 2021 - National Acad Sciences
Asthma often worsens at night. To determine if the endogenous circadian system contributes
to the nocturnal worsening of asthma, independent of sleep and other behavioral and …
to the nocturnal worsening of asthma, independent of sleep and other behavioral and …
Upregulation of LncRNA Malat1 Induced Proliferation and Migration of Airway Smooth Muscle Cells via miR-150-eIF4E/Akt Signaling
L Lin, Q Li, W Hao, Y Zhang, L Zhao, W Han - Frontiers in physiology, 2019 - frontiersin.org
The increased proliferation and migration of airway smooth muscle cells (ASMCs) are critical
processes in the formation of airway remodeling in asthma. Long non-coding RNAs …
processes in the formation of airway remodeling in asthma. Long non-coding RNAs …
Cell-specific activation profile of extracellular signal-regulated kinase 1/2, Jun N-terminal kinase, and p38 mitogen-activated protein kinases in asthmatic airways
W Liu, Q Liang, S Balzar, S Wenzel, M Gorska… - Journal of Allergy and …, 2008 - Elsevier
BACKGROUND: Many airway cells manifest signs of chronic activation in asthma. The
mechanism of this chronic activation is unknown. OBJECTIVES: We sought to study the …
mechanism of this chronic activation is unknown. OBJECTIVES: We sought to study the …
An official American Thoracic Society research statement: current challenges facing research and therapeutic advances in airway remodeling
YS Prakash, AJ Halayko, R Gosens… - American Journal of …, 2017 - atsjournals.org
Background: Airway remodeling (AR) is a prominent feature of asthma and other obstructive
lung diseases that is minimally affected by current treatments. The goals of this Official …
lung diseases that is minimally affected by current treatments. The goals of this Official …
Do biophysical properties of the airway smooth muscle in culture predict airway hyperresponsiveness?
Airway hyperresponsiveness is a cardinal feature of asthma but remains largely
unexplained. In asthma, the key end-effector of acute airway narrowing is the airway smooth …
unexplained. In asthma, the key end-effector of acute airway narrowing is the airway smooth …
[HTML][HTML] COPD-associated miR-145-5p is downregulated in early-decline FEV1 trajectories in childhood asthma
Background Many microRNAs (miRNAs) have been associated with asthma and chronic
obstructive pulmonary disease (COPD). Longitudinal lung function growth trajectories of …
obstructive pulmonary disease (COPD). Longitudinal lung function growth trajectories of …