Dopamine, immunity, and disease
B Channer, SM Matt, EA Nickoloff-Bybel, V Pappa… - Pharmacological …, 2023 - ASPET
The neurotransmitter dopamine is a key factor in central nervous system (CNS) function,
regulating many processes including reward, movement, and cognition. Dopamine also …
regulating many processes including reward, movement, and cognition. Dopamine also …
Inflammation in Parkinson's disease: mechanisms and therapeutic implications
M Pajares, A I. Rojo, G Manda, L Boscá, A Cuadrado - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
by the death of dopaminergic neurons that project from the substantia nigra pars compacta …
Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice
S Li, Y Fang, Y Zhang, M Song, X Zhang, X Ding… - Cell reports, 2022 - cell.com
The function and regulation of different heterogeneous reactive states of astrocytes in
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …
depression remain unclear. Here, we demonstrate that neurotoxic reactive (A1-like) …
Fiery cell death: pyroptosis in the central nervous system
Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
Blocking meningeal lymphatic drainage aggravates Parkinson's disease-like pathology in mice overexpressing mutated α-synuclein
W Zou, T Pu, W Feng, M Lu, Y Zheng, R Du… - Translational …, 2019 - Springer
Background Abnormal aggregation of brain α-synuclein is a central step in the pathogenesis
of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to …
of Parkinson's disease (PD), thus, it is reliable to promote the clearance of α-synuclein to …
Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease
Excessive activation of microglia and subsequent release of proinflammatory cytokines play
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …
a crucial role in neuroinflammation and neurodegeneration in Parkinson's disease (PD) …
Neuroinflammation and Parkinson's disease—From neurodegeneration to therapeutic opportunities
B Araújo, R Caridade-Silva, C Soares-Guedes… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …
worldwide. Clinically, it is characterized by a progressive degeneration of dopaminergic …
Neuron-astrocyte interactions in Parkinson's disease
I Miyazaki, M Asanuma - Cells, 2020 - mdpi.com
Parkinson's disease (PD) is the second most common neurodegenerative disease. PD
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …
patients exhibit motor symptoms such as akinesia/bradykinesia, tremor, rigidity, and postural …
The role of dopamine in NLRP3 inflammasome inhibition: Implications for neurodegenerative diseases
Abstract In the Central Nervous System (CNS), neuroinflammation orchestrated by microglia
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
and astrocytes is an innate immune response to counteract stressful and dangerous insults …
NLRP3 inflammasome in neurodegenerative disease
FL Anderson, KE Biggs, BE Rankin, MC Havrda - Translational Research, 2023 - Elsevier
Neurodegenerative diseases are characterized by a dysregulated neuro-glial
microenvironment, culminating in functional deficits resulting from neuronal cell death …
microenvironment, culminating in functional deficits resulting from neuronal cell death …