Signal transducer and activator of transcription 3 (STAT3) was recently found to be localized
to mitochondria in a number of tissues and cell types, where it modulates oxidative …

Regulation of cellular death is central to nearly all physiological routines and is dysregulated
in virtually all diseases. Cell death occurs by two major processes, necrosis which …

The unusual pattern of expression of hemoglobin (Hb) and myoglobin (Mb) among Antarctic
notothenioid fishes provides an exceptional model system for assessing the impact of these …

Kubat et al. provide a review on the role Mitochondrial density in skeletal and cardiac
muscle of mitochondrial dysfunction in muscle atrophy. They stress mitochondria's pivotal …

Mitochondrion provides much of the energy for the cell and the disorder in mitochondrion
can affect almost any tissue [1]. The mitochondrial DNA (mtDNA) covers 16,569 bp …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Increasing evidence points towards mitochondria as crucial players in the initiation and
progression of auto-immune and degenerative disorders, to which impaired cell metabolism …

Reactive oxygen species (ROS) are implicated in cardiovascular and neurologic disorders
including atherosclerosis, heart attack, stroke, and traumatic brain injury. Although oxidative …

The blood-brain barrier (BBB) acts as the crucial protective structure in the central nervous
system (CNS). Here we showed that a subset of astrocytes marked by Dmp1 expression …

Abstract MCL1 (myeloid cell leukemia-1) is a widely recognized pro-survival member of the
Bcl-2 (B-cell lymphoma protein 2) family and a promising target for cancer therapy. While the …