Mock circulatory loop applications for testing cardiovascular assist devices and in vitro studies

KW Xu, Q Gao, M Wan, K Zhang - Frontiers in Physiology, 2023 - frontiersin.org
The mock circulatory loop (MCL) is an in vitro experimental system that can provide
continuous pulsatile flows and simulate different physiological or pathological parameters of …

Mock circulatory loops used for testing cardiac assist devices: A review of computational and experimental models

F Cappon, T Wu, T Papaioannou, X Du… - … Journal of Artificial …, 2021 - journals.sagepub.com
Heart failure is a major health risk, and with limited availability of donor organs, there is an
increasing need for developing cardiac assist devices (CADs). Mock circulatory loops (MCL) …

A hybrid mock circulatory loop for fluid dynamic characterization of 3D anatomical phantoms

F Bardi, E Gasparotti, E Vignali… - IEEE Transactions on …, 2022 - ieeexplore.ieee.org
Goal: This work presents the development of a Hybrid Mock Circulatory Loop (HMCL) to
simulate hemodynamics at patient-specific level in terms of both 3D geometry and …

3D printing in modern cardiology

S Celi, E Gasparotti, K Capellini… - Current …, 2021 - ingentaconnect.com
Background: 3D printing represents an emerging technology in the field of cardiovascular
medicine. 3D printing can help to perform a better analysis of complex anatomies to optimize …

A mock circulation loop to characterize in vitro hemodynamics in human systemic arteries with stenosis

W Hong, H Yu, J Chen, J Talamantes, DM Rollins… - Fluids, 2023 - mdpi.com
Vascular disease is the leading cause of morbidity and mortality and a major cause of
disability for Americans, and arterial stenosis is its most common form in systemic arteries …

Study on the hemodynamic effects of different pulsatile working modes of a rotary blood pump using a microfluidic platform that realizes in vitro cell culture effectively

L Liang, X Wang, D Chen, P Sethu, GA Giridharan… - Lab on a Chip, 2024 - pubs.rsc.org
Rotary blood pumps (RBPs) operating at a constant speed generate non-physiologic blood
pressure and flow rate, which can cause endothelial dysfunction, leading to adverse clinical …

Object‐Oriented Lumped‐Parameter Modeling of the Cardiovascular System for Physiological and Pathophysiological Conditions

L Rosalia, C Ozturk, D Van Story… - Advanced theory …, 2021 - Wiley Online Library
In this work, a lumped‐parameter Windkessel model of the cardiovascular system that
simulates biomechanical parameters of the human physiology is presented. The object …

A mock circulation loop to evaluate differential hypoxemia during peripheral venoarterial extracorporeal membrane oxygenation

S Rozencwajg, EL Wu, S Heinsar, M Stevens… - …, 2024 - journals.sagepub.com
Introduction Peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO)
creates a retrograde flow along the aorta competing with the left ventricle (LV) in the so …

In vitro major arterial cardiovascular simulator to generate benchmark data sets for in silico model validation

M Wisotzki, A Mair, P Schlett, B Lindner, M Oberhardt… - Data, 2022 - mdpi.com
Cardiovascular diseases are commonly caused by atherosclerosis, stenosis and
aneurysms. Understanding the influence of these pathological conditions on the circulatory …

Watershed phenomena during extracorporeal life support and their clinical impact: a systematic in vitro investigation

J Gehron, M Schuster, F Rindler, M Bongert… - ESC heart …, 2020 - Wiley Online Library
Aims Extracorporeal life support (ECLS) during acute cardiac failure restores
haemodynamic stability and provides life‐saving cardiopulmonary support. Unfortunately, all …