The innate immune system is the only defence weapon of invertebrates and a fundamental
defence mechanism of fish. The innate system also plays an instructive role in the acquired …

Chemokine CXC motif ligand 13 (CXCL13), originally identified as a B-cell chemokine, plays
an important role in the immune system. The interaction between CXCL13 and its receptor …

B1 cells are a predominant cell type in body cavities and an important source of natural
antibody. Here we report that in mice lacking the chemokine, CXCL13, B1 cells are deficient …

Abstract Purpose of Review During the last decades, obesity and autoimmune disorders
have shown a parallel significant rise in industrialized countries. This review aims at …

Antibodies that are present in the serum of healthy individuals in the absence of deliberate
immunization with any antigen, are refered to as natural antibodies. A vast majority of natural …

Several transplant patients maintain stable kidney graft function in the absence of
immunosuppression. Here we compared the characteristics of their peripheral B cells to that …

Most natural IgM antibodies are encoded by germline Ig sequences and are produced in
large quantities by both mice and humans in the absence of intentional immunization …

Background: Heterophile antibodies interfere with immunoassays. Understanding the nature
and characteristics of these antibodies provides a format for better identifying and removing …

Secretory immunoglobulin A (S-IgA) was investigated in human secretions for the presence
of natural antibodies (Abs) acting as the first" immune barrier" to infection before induction or …

In the era towards precision medicine, we here present the individual specific autoantibody
signatures of 193 healthy individuals. The self-reactive IgG signatures are stable over time in …