Myelofibrosis (MF) is a life-threatening blood cancer characterized by progressive bone
marrow fibrosis, splenomegaly, cytopenias, and debilitating constitutional symptoms …

Interferon-alpha (IFNα) has emerged as an important regulator of growth and differentiation,
affecting cellular communication and signal transduction pathways as well as immunological …

DISCUSSION Miles et al. 8 studied the effect of interferon beta in patients with AIDS-related
Kaposi's sarcoma. They noted ulceration in eight of 39 patients, with more of these adverse …

Cytokines are pleiotropic molecules showing a wide variety of biologic functions on various
cells and tissues, and several different cytokines exert similar and overlapping functions on …

Type I interferons (IFNs) are the first line of defence after various infections, and, as
immunomodulatory cytokines, bridge innate and adaptive immunity. IL-17, mainly secreted …

With interleukins (IL), a new class of potential drugs has been introduced into clinical
research. These signal peptides are involved in the regulation of many physiological and …

Cytokines are pleiotropic molecules showing a wide variety of biological functions on
various cells and tissues. Several different cytokines exert similar and overlapping functions …

The genes crucially determining the therapeutic response of chronic myelogenous
leukaemia (CML) to interferon‐alpha (IFN‐alpha) are unknown. Recently, two independent …

Objectives: This study compared the pharmacodynamics and tolerability of subcutaneous
6MU (22μg) interferon (IFN)-β-la (Rebif®) and 8MU (250μg) IFN-β-1b (Betaseron®) …

Beta-2-microglobulin (B2M) forms the small invariable light chain subunit of the class I HLA
antigens on the cell membrane of all nucleated cells. During the continuous turnover of the …