Beyond the factor indeterminacy problem using genome-wide association data

ML Clapp Sullivan, T Schwaba, KP Harden… - Nature human …, 2024 - nature.com
Latent factors, such as general intelligence, depression and risk tolerance, are invoked in
nearly all social science research where a construct is measured via aggregation of …

More than nature and nurture, indirect genetic effects on children's academic achievement are consequences of dynastic social processes

MG Nivard, DW Belsky, KP Harden, T Baier… - Nature Human …, 2024 - nature.com
Abstract Families transmit genes and environments across generations. When parents'
genetics affect their children's environments, these two modes of inheritance can produce an …

Genetic and molecular architecture of complex traits

T Lappalainen, YI Li, S Ramachandran, A Gusev - Cell, 2024 - cell.com
Human genetics has emerged as one of the most dynamic areas of biology, with a
broadening societal impact. In this review, we discuss recent achievements, ongoing efforts …

Tree-based QTL mapping with expected local genetic relatedness matrices

V Link, JG Schraiber, C Fan, B Dinh, N Mancuso… - The American Journal of …, 2023 - cell.com
Understanding the genetic basis of complex phenotypes is a central pursuit of genetics.
Genome-wide association studies (GWASs) are a powerful way to find genetic loci …

[HTML][HTML] Causal interpretations of family GWAS in the presence of heterogeneous effects

C Veller, M Przeworski, G Coop - bioRxiv, 2023 - ncbi.nlm.nih.gov
Family-based genome-wide association studies (GWAS) have emerged as a gold standard
for assessing causal effects of alleles and polygenic scores. Notably, family studies are often …

[HTML][HTML] Genetic associations between non-cognitive skills and academic achievement over development

M Malanchini, AG Allegrini, MG Nivard, P Biroli… - Nature Human …, 2024 - nature.com
Non-cognitive skills, such as motivation and self-regulation, are partly heritable and predict
academic achievement beyond cognitive skills. However, how the relationship between non …

Polygenic Indices (aka Polygenic Scores) in Social Science: A Guide for Interpretation and Evaluation

CH Burt - Sociological Methodology, 2024 - journals.sagepub.com
Polygenic indices (PGI)—the new recommended label for polygenic scores in social science
applications—are genetic summary scales often used to represent an individual's liability for …

[HTML][HTML] Estimation of indirect genetic effects and heritability under assortative mating

AS Young - bioRxiv, 2023 - ncbi.nlm.nih.gov
Both direct genetic effects (effects of alleles in an individual on that individual) and indirect
genetic effects—effects of alleles in an individual (eg parents) on another individual (eg …

[HTML][HTML] Genetic contributions of noncognitive skills to academic development

M Malanchini, AG Allegrini, MG Nivard, P Biroli… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Noncognitive skills such as motivation and self-regulation, are partly heritable and predict
academic achievement beyond cognitive skills. However, how the relationship between …

[HTML][HTML] Examining intergenerational risk factors for conduct problems using polygenic scores in the Norwegian Mother, Father and Child Cohort Study

L Frach, W Barkhuizen, AG Allegrini, H Ask… - Molecular …, 2024 - nature.com
The aetiology of conduct problems involves a combination of genetic and environmental
factors, many of which are inherently linked to parental characteristics given parents' central …