Tolerance and resistance of microbial biofilms

O Ciofu, C Moser, PØ Jensen, N Høiby - Nature Reviews Microbiology, 2022 - nature.com
Chronic infections caused by microbial biofilms represent an important clinical challenge.
The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major …

Mechanisms and clinical importance of bacteriophage resistance

JE Egido, AR Costa… - FEMS microbiology …, 2022 - academic.oup.com
We are in the midst of a golden age of uncovering defense systems against bacteriophages.
Apart from the fundamental interest in these defense systems, and revolutionary applications …

Current challenges and future opportunities of phage therapy

DP Pires, AR Costa, G Pinto, L Meneses… - FEMS microbiology …, 2020 - academic.oup.com
Antibiotic resistance is a major public health challenge worldwide, whose implications for
global health might be devastating if novel antibacterial strategies are not quickly …

Understanding the impacts of bacteriophage viruses: from laboratory evolution to natural ecosystems

B Koskella, CA Hernandez… - Annual Review of …, 2022 - annualreviews.org
Viruses of bacteria (bacteriophages or phage) have broad effects on bacterial ecology and
evolution in nature that mediate microbial interactions, shape bacterial diversity, and …

[HTML][HTML] Translating phage therapy into the clinic: recent accomplishments but continuing challenges

A Petrovic Fabijan, J Iredell, K Danis-Wlodarczyk… - Plos …, 2023 - journals.plos.org
Phage therapy is a medical form of biological control of bacterial infections, one that uses
naturally occurring viruses, called bacteriophages or phages, as antibacterial agents …

Drivers and consequences of bacteriophage host range

D Holtappels, P Alfenas-Zerbini… - FEMS Microbiology …, 2023 - academic.oup.com
Bacteriophages are obligate parasites of bacteria characterized by the breadth of hosts that
they can infect. This “host range” depends on the genotypes and morphologies of the phage …

Biological foundations of successful bacteriophage therapy

C Venturini, A Petrovic Fabijan… - EMBO Molecular …, 2022 - embopress.org
Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Eradicating biofilm infections: an update on current and prospective approaches

RAG da Silva, I Afonina, KA Kline - Current Opinion in Microbiology, 2021 - Elsevier
Highlights•Biofilm infections are heterogenous, persistent and recalcitrant.•The rise of
antibiotic resistance necessitates new therapeutic strategies to eradicate biofilms.•The …

Understanding the complex phage-host interactions in biofilm communities

DP Pires, LDR Melo, J Azeredo - Annual Review of Virology, 2021 - annualreviews.org
Bacteriophages and bacterial biofilms are widely present in natural environments, a fact that
has accelerated the evolution of phages and their bacterial hosts in these particular niches …

Bacteriophage–a promising alternative measure for bacterial biofilm control

F Tian, J Li, A Nazir, Y Tong - Infection and Drug Resistance, 2021 - Taylor & Francis
Bacterial biofilms can enhance bacteria's viability by providing resistance against antibiotics
and conventional disinfectants. The existence of biofilm is a serious threat to human health …