Ischemic stroke (IS) is one of the major types of cerebrovascular diseases causing
neurological morbidity and mortality worldwide. In the pathophysiological process of IS …

Aging can cause attenuation in the functioning of multiple organs, and blood-brain barrier
(BBB) breakdown could promote the occurrence of disorders of the central nervous system …

Astrocytes are intimately linked with brain blood vessels, an essential relationship for
neuronal function. However, astroglial factors driving these physical and functional …

Background. The extracellular matrix of the PNS/CNS is unusual in that it is dominated by
glycosaminoglycans, especially hyaluronan, whose space filling and hydrating properties …

Cognitive impairment (CI) is a major health concern in aging populations. It impairs patients'
independent life and may progress to dementia. Vascular cognitive impairment (VCI) …

Background Coupling between neuronal activity and blood perfusion is termed
neurovascular coupling (NVC), and it provides a potentially new mechanistic perspective …

Abstract Background Type 2 Diabetes Mellitus (T2DM) patients are twice as likely to develop
dementia. The study's goal was to evaluate cognitive performance and risk factors for …

The neurovascular unit (NVU) reflects the close temporal and spatial link between neurons
and blood vessels. However, the understanding of the NVU in the spinal cord is far from …

The Danshen-Honghua (DH) herbal pair exhibits a synergistic effect in protecting the
cerebrovascular system from ischemia/reperfusion injury, but the therapeutic effect on …

Abstract Background Vascular dementia (VaD) is the second most common type of dementia
after Alzheimer's disease. Currently, no FDA-approved drugs are available for the treatment …