Early life stressors display a high universal prevalence and constitute a major public health
problem. Prolonged psychoneurobiological alterations as sequelae of early life stress (ELS) …

A healthy nutritional state is required for all aspects of reproduction and is signaled by the
adipokine leptin. Leptin acts in a relatively narrow concentration range: too much or too little …

Obesity is a major health crisis affecting over a third of the global population. This
multifactorial disease is regulated via interoceptive neural circuits in the brain, whose …

Obesity increases the risk for metabolic, cardiovascular, chronic inflammatory, and several
malignant diseases and, therefore, may contribute to shortened lifespan. Adipokines are …

Leptin is secreted by adipose tissue and regulates energy homeostasis, neuroendocrine
function, metabolism, immune function and other systems through its effects on the central …

This year marks the 20th anniversary of the discovery of leptin, which has tremendously
stimulated translational obesity research. The discovery of leptin has led to realizations that …

T cell activation leads to dramatic shifts in cell metabolism to protect against pathogens and
to orchestrate the action of other immune cells. Quiescent T cells require predominantly ATP …

Excessive body weight and obesity in childhood and adolescence are becoming more and
more important unfavorable factors that entail extremely adverse consequences and require …

Like the obesity epidemic, our understanding of adipocytes and adipose tissue is
expanding. Just in the past decade, substantial advances have led to new insights into the …

Metabolic syndrome (MetS) and thyroid dysfunction are common in clinical practice. The
objectives of this review are to discuss some proposed mechanisms by which thyroid …