[HTML][HTML] Designing spatial and temporal control of vaccine responses

GA Roth, VCTM Picece, BS Ou, W Luo… - Nature Reviews …, 2022 - nature.com
Vaccines are the key technology to combat existing and emerging infectious diseases.
However, increasing the potency, quality and durability of the vaccine response remains a …

[HTML][HTML] Hypes, hopes, and the way forward for microalgal biotechnology

MJ Barbosa, M Janssen, C Südfeld, S D'Adamo… - Trends in …, 2023 - cell.com
The urge for food security and sustainability has advanced the field of microalgal
biotechnology. Microalgae are microorganisms able to grow using (sun) light, fertilizers …

Transdermal vaccination via 3D-printed microneedles induces potent humoral and cellular immunity

C Caudill, JL Perry, K Iliadis… - Proceedings of the …, 2021 - National Acad Sciences
Vaccination is an essential public health measure for infectious disease prevention. The
exposure of the immune system to vaccine formulations with the appropriate kinetics is …

A single immunization with spike-functionalized ferritin vaccines elicits neutralizing antibody responses against SARS-CoV-2 in mice

AE Powell, K Zhang, M Sanyal, S Tang… - ACS central …, 2021 - ACS Publications
The development of a safe and effective SARS-CoV-2 vaccine is a public health priority. We
designed subunit vaccine candidates using self-assembling ferritin nanoparticles displaying …

[HTML][HTML] Antimicrobial resistance and recent alternatives to antibiotics for the control of bacterial pathogens with an emphasis on foodborne pathogens

YA Helmy, K Taha-Abdelaziz, HAEH Hawwas, S Ghosh… - Antibiotics, 2023 - mdpi.com
Antimicrobial resistance (AMR) is one of the most important global public health problems.
The imprudent use of antibiotics in humans and animals has resulted in the emergence of …

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

[HTML][HTML] Peptide-based synthetic vaccines

M Skwarczynski, I Toth - Chemical science, 2016 - pubs.rsc.org
Classically all vaccines were produced using live or attenuated microorganisms or parts of
them. However, the use of whole organisms, their components or the biological process for …

Antigens reversibly conjugated to a polymeric glyco-adjuvant induce protective humoral and cellular immunity

DS Wilson, S Hirosue, MM Raczy, L Bonilla-Ramirez… - Nature materials, 2019 - nature.com
Fully effective vaccines for complex infections must elicit a diverse repertoire of antibodies
(humoral immunity) and CD8+ T-cell responses (cellular immunity). Here, we present a …

Multifaceted roles of disulfide bonds. Peptides as therapeutics

M Gongora-Benitez, J Tulla-Puche… - Chemical Reviews, 2014 - ACS Publications
In the last century, small-molecule natural products were the main inspiration for most drug
discovery programs based either on high-throughput screening (HTS) or rational design …

[HTML][HTML] Advances in infectious disease vaccine adjuvants

J Fan, S Jin, L Gilmartin, I Toth, WM Hussein… - Vaccines, 2022 - mdpi.com
Vaccines are one of the most significant medical interventions in the fight against infectious
diseases. Since their discovery by Edward Jenner in 1796, vaccines have reduced the …