Plasticity in developmental programming has evolved in order to provide the best chances of
survival and reproductive success to the organism under changing environments …

The insulin-like growth factor (IGF) system comprises two ligands, IGF-I and IGF-II, that
regulate multiple physiological processes, including mammalian development, metabolism …

Provide the best care possible with expert insight and clinically relevant coverage of the
physiologic changes that occur throughout all major periods of the perinatal experience …

Puberty is a defining phase of human development where growth ends and the ability to
reproduce begins. An understanding of the events leading up to puberty highlights the fact …

Depending on the definitions used, up to 10% of all live-born neonates are small for
gestational age (SGA). Although the vast majority of these children show catch-up growth by …

In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction;
however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking …

Monogenic diabetes results from one or more defects in a single gene. The disease may be
inherited within families as a dominant, recessive, or non-Mendelian trait or may present as …

One of the fundamental questions in developmental biology is how the vast range of pattern
and structure we observe in nature emerges from an almost uniformly homogeneous …

Receptor tyrosine kinases (RTKs) play essential roles in cellular processes, including
metabolism, cell-cycle control, survival, proliferation, motility and differentiation. RTKs are all …

Maternal diabetes constitutes an unfavorable environment for embryonic and fetoplacental
development. Despite current treatments, pregnant women with pregestational diabetes are …