Simple Summary Integrins, a superfamily of cell adhesion receptors, were extensively
investigated as therapeutic targets over the last decades, motivated by their multiple …

Molecular imaging for non-invasive assessment of angiogenesisis is of great interest for
clinicians because of the wide-spread application of anti-angiogenic cancer therapeutics …

Drug conjugates have become a significant focus of research in the field of targeted
medicine for cancer treatments. Peptide-drug conjugates (PDCs), a subset of drug …

Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …

Integrin αvβ3 plays a significant role in tumor angiogenesis and is a receptor for the
extracellular matrix proteins with the exposed arginine-glycine-aspartic (RGD) tripeptide …

Imaging of angiogenesis has become increasingly important with the rising use of targeted
antiangiogenic therapies like bevacizumab (Avastin). Non-invasive assessment of …

Peptide receptor radionuclide therapy (PRRT) is a site-directed targeted therapeutic strategy
that specifically uses radiolabeled peptides as biological targeting vectors designed to …

In recent years the importance of molecular and diagnostic imaging has increased
dramatically in the treatment planning of many diseases and in particular in cancer therapy …

PET with 18F-labeled arginine-glycine-aspartic acid (RGD) peptides can visualize and
quantify ανβ3 integrin expression in patients, but radiolabeling is complex and image …

Angiogenesis is a requirement for tumor growth and metastasis. The angiogenic process
depends on vascular endothelial cell migration and invasion, and is regulated by various …