Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine
Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …
now can generate most cells of the human body in the laboratory. PSC-derived …
Advances in regenerative medicine and tissue engineering: innovation and transformation of medicine
Humans and animals lose tissues and organs due to congenital defects, trauma, and
diseases. The human body has a low regenerative potential as opposed to the urodele …
diseases. The human body has a low regenerative potential as opposed to the urodele …
[HTML][HTML] A spatiotemporal organ-wide gene expression and cell atlas of the developing human heart
The process of cardiac morphogenesis in humans is incompletely understood. Its full
characterization requires a deep exploration of the organ-wide orchestration of gene …
characterization requires a deep exploration of the organ-wide orchestration of gene …
Single-cell transcriptome analysis maps the developmental track of the human heart
The heart is the central organ of the circulatory system, and its proper development is vital
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
for maintaining human life. Here, we used single-cell RNA sequencing to profile the gene …
WNT signaling in cardiac and vascular disease
S Foulquier, EP Daskalopoulos, G Lluri… - Pharmacological …, 2018 - ASPET
WNT signaling is an elaborate and complex collection of signal transduction pathways
mediated by multiple signaling molecules. WNT signaling is critically important for …
mediated by multiple signaling molecules. WNT signaling is critically important for …
Genetics of congenital heart disease
K Williams, J Carson, C Lo - Biomolecules, 2019 - mdpi.com
Congenital heart disease (CHD) is one of the most common birth defects. Studies in animal
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
models and humans have indicated a genetic etiology for CHD. About 400 genes have been …
Development of the human heart
MFJ Buijtendijk, P Barnett… - American Journal of …, 2020 - Wiley Online Library
In 2014, an extensive review discussing the major steps of cardiac development focusing on
growth, formation of primary and chamber myocardium and the development of the cardiac …
growth, formation of primary and chamber myocardium and the development of the cardiac …
Integrative single-cell analysis of cardiogenesis identifies developmental trajectories and non-coding mutations in congenital heart disease
To define the multi-cellular epigenomic and transcriptional landscape of cardiac cellular
development, we generated single-cell chromatin accessibility maps of human fetal heart …
development, we generated single-cell chromatin accessibility maps of human fetal heart …
Single-nucleotide variants within heart enhancers increase binding affinity and disrupt heart development
GA Jindal, AT Bantle, JJ Solvason, JL Grudzien… - Developmental Cell, 2023 - cell.com
Transcriptional enhancers direct precise gene expression patterns during development and
harbor the majority of variants associated with phenotypic diversity, evolutionary …
harbor the majority of variants associated with phenotypic diversity, evolutionary …
[HTML][HTML] BMP10 signaling promotes the development of endocardial cells from human pluripotent stem cell-derived cardiovascular progenitors
The embryonic endocardium is essential for early heart development as it functions to
induce trabecular myocardium, the first heart tissue to form, and is the source of the cells that …
induce trabecular myocardium, the first heart tissue to form, and is the source of the cells that …