Life and death of peripheral lymphocytes is strictly controlled to maintain physiologic levels
of T and B cells. Activation-induced cell death (AICD) is one mechanism to delete …

A defined human microbiota‐associated (HMA) mouse model in BALB/c and
immunodeficient Tgε26 mice was used to assess the ability of probiotic lactobacilli and …

MHC class II expression identifies an effector subset of human CD4+ CD25 high FoxP3 high
natural regulatory T cells (DR+ Tregs) that induces more rapid suppression and exhibits …

The TNF superfamily member Fas ligand acts as a prototypic death factor. Due to its ability to
induce apoptosis in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential …

Group B streptococcus (GBS) is part of the normal genital and gastrointestinal flora in
healthy humans. However, GBS is a major cause of sepsis and meningitis in newborn …

Background Rasmussen encephalitis (RE) is a rare complex inflammatory disease, primarily
seen in young children, that is characterized by severe partial seizures and brain atrophy …

During apoptosis, physical changes in the plasma membrane prepare the cell for clearance
by phagocytes and hydrolysis by secretory phospholipase A 2 (sPLA 2). The relationships …

T cell homeostasis is critical for the proper function of the immune system. Following the
sharp expansion upon pathogen infection, most T cells die in order to keep balance in the …

The peptidyl prolyl isomerase (PPIase) Pin1 has been recently implicated in cell cycle
control and neuropathologies. There is now growing evidence that Pin1 plays an important …

TNF-α has been identified as a major mediator in the pathophysiology of inflammation. Anti-
TNF agents, either as a neutralising antibody or a soluble TNF receptor, have markedly …