Dosimetry of bone seeking beta emitters for bone pain palliation metastases

K Liepe, I Murray, G Flux - Seminars in Nuclear Medicine, 2022 - Elsevier
Amongst cancer patients, bone pain due to skeletal metastases is a major cause of
morbidity. A number of beta-emitting radiopharmaceuticals have been used to provide …

Feasibility and limitations of quantitative SPECT for 223Ra

J Gustafsson, E Rodeño… - Physics in Medicine & …, 2020 - iopscience.iop.org
The aim of this paper is to investigate the feasibility and limitations of activity-concentration
estimation for 223 Ra using SPECT. Phantom measurements are performed using spheres …

Biodistribution and dosimetry of 177Lu-DOTA-IBA for therapy of bone metastases

H Li, W Pei, X Yang, G Qu, Q Hua, L Liu, Y Wang, T Xu… - EJNMMI research, 2024 - Springer
Background We designed and synthesized a novel bisphosphonate radiopharmaceutical
(68 Ga-or 177Lu-labeled DOTA-ibandronate [68 Ga/177Lu-DOTA-IBA]) for the targeted …

Targeted therapy for metastatic prostate cancer with radionuclides

H Ahmadzadehfar - Prostate Cancer–Leading–Edge Diagnostic …, 2016 - books.google.com
Progression to androgen-independent status is the main cause of death in patients with
metastatic prostate cancer. Prostate-specific membrane antigen (PSMA) is anchored in the …

Response to 223RaCl2 or 177Lu-iPSMA treatment in bone metastases due to castration-resistant prostate cancer as a function of absorbed dose

JG Villagrana-Velázquez, K Isaac-Olivé… - Radiation Physics and …, 2024 - Elsevier
A newer therapy for the treatment of bone metastases due to castration-resistant prostate
cancer (mCRPC) is the administration of 223 Ra-dichloride (223 RaCl 2) or 177 Lu-iPSMA …

Preclinical single photon emission computed tomography of alpha particle-emitting radium-223

DS Abou, A Rittenbach, RE Tomlinson… - Cancer Biotherapy & …, 2020 - liebertpub.com
Objective: Dose optimization and pharmacokinetic evaluation of α-particle emitting radium-
223 dichloride (223RaCl2) by planar γ-camera or single photon emission computed …

Individualization of radionuclide therapies: challenges and prospects

H Piwowarska-Bilska, S Kurkowska, B Birkenfeld - Cancers, 2022 - mdpi.com
Simple Summary Currently, patient-specific treatment plans and dosimetry calculations are
not routinely performed for radionuclide therapies. In external beam radiotherapy, it is quite …

Milestones in dosimetry for nuclear medicine therapy

J Gear - The British Journal of Radiology, 2022 - academic.oup.com
Nuclear Medicine therapy has reached a critical juncture with an unprecedented number of
patients being treated and an extensive list of new radiopharmaceuticals under …

Is there a flare phenomenon on bone scintigraphy in men with advanced prostate cancer treated with radium-223?

G Isensee, A Péporté, J Müller, S Schmid… - Clinical genitourinary …, 2018 - Elsevier
Introduction Radium-223 is an approved survival-prolonging treatment option in men with
castration-resistant prostate cancer (mCRPC) and bone metastases. In the registration trial …

Recent advances in the development of 225Ac- and 211At-labeled radioligands for radiotheranostics

M Munekane, T Fuchigami, K Ogawa - Analytical Sciences, 2024 - Springer
Radiotheranostics utilizes a set of radioligands incorporating diagnostic or therapeutic
radionuclides to achieve both diagnosis and therapy. Imaging probes using diagnostic …