The Abelson (ABL) family of nonreceptor tyrosine kinases, ABL1 and ABL2, transduces
diverse extracellular signals to protein networks that control proliferation, survival, migration …

Translocations involving band 12p13 are one of the most commonly observed chromosomal
abnormalities in human leukemia and myelodysplastic syndrome. Their frequently result in …

Genomic profiling has identified a subtype of high-risk B-progenitor acute lymphoblastic
leukemia (B-ALL) with alteration of IKZF1, a gene expression profile similar to BCR-ABL1 …

Genomic events associated with poor outcome in chronic myeloid leukemia (CML) are
poorly understood. We performed whole-exome sequencing, copy-number variation, and/or …

Purpose: Salivary duct carcinoma (SDC) is an aggressive salivary malignancy, which is
resistant to chemotherapy and has high mortality rates. We investigated the molecular …

Abl kinases are prototypic cytoplasmic tyrosine kinases and are involved in a variety of
chromosomal aberrations in different cancers. This causes the expression of Abl fusion …

Based on new data and increased understanding of disease molecular genetics, the
international consensus classification (ICC) has made several changes in the diagnosis and …

This review addresses changes and updates in eosinophilic disorders under the
International Consensus Classification (ICC). The previous category of myeloid/lymphoid …

The nuclear pore complex (NPC) mediates trafficking between the cytoplasm and
nucleoplasm. It also plays key roles in other nuclear processes such as chromatin silencing …

Chronic myeloid leukemia (CML) is driven by the constitutive activity of the BCR-ABL1 fusion
oncoprotein. Despite the great success of drugs that target the BCR-ABL1 ATP-binding site …