[HTML][HTML] Pharmacology and rationale for seralutinib in the treatment of pulmonary arterial hypertension
SS Pullamsetti, R Sitapara, R Osterhout… - International Journal of …, 2023 - mdpi.com
Pulmonary arterial hypertension (PAH) is a complex disorder characterized by vascular
remodeling and a consequent increase in pulmonary vascular resistance. The histologic …
remodeling and a consequent increase in pulmonary vascular resistance. The histologic …
[HTML][HTML] Hypoxia-induced pulmonary hypertension in adults and newborns: implications for drug development
Chronic hypoxia-induced pulmonary hypertension (CHPH) presents a complex challenge,
characterized by escalating pulmonary vascular resistance and remodeling, threatening …
characterized by escalating pulmonary vascular resistance and remodeling, threatening …
Corosolic acid attenuates platelet-derived growth factor signaling in macrophages and smooth muscle cells of pulmonary arterial hypertension
A Yamamura, M Fujiwara, A Kawade, T Amano… - European Journal of …, 2024 - Elsevier
Pulmonary arterial hypertension (PAH) is a progressive and life-threatening disease that is
characterized by vascular remodeling of the pulmonary artery. Pulmonary vascular …
characterized by vascular remodeling of the pulmonary artery. Pulmonary vascular …
[HTML][HTML] Lactate facilitated mitochondrial fission-derived ROS to promote pulmonary fibrosis via ERK/DRP-1 signaling
Z Sun, Z Ji, H Meng, W He, B Li, X Pan, Y Zhou… - Journal of Translational …, 2024 - Springer
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung diseases,
which mainly existed in middle-aged and elderly people. The accumulation of reactive …
which mainly existed in middle-aged and elderly people. The accumulation of reactive …
[HTML][HTML] Systemic Sclerosis-Associated Pulmonary Arterial Hypertension: From Bedside to Bench and Back Again
M Bahi, C Li, G Wang, BD Korman - International Journal of Molecular …, 2024 - mdpi.com
Systemic sclerosis (SSc) is a heterogeneous disease characterized by autoimmunity,
vasculopathy, and fibrosis which affects the skin and internal organs. One key aspect of SSc …
vasculopathy, and fibrosis which affects the skin and internal organs. One key aspect of SSc …
[HTML][HTML] β-catenin mediates monocrotaline-induced pulmonary hypertension via glycolysis in rats
H Meng, Y Deng, J Liao, D Wu, L Li, X Chen… - BMC Cardiovascular …, 2024 - Springer
Background Metabolic abnormalities and immune inflammation are deeply involved in
pulmonary vascular remodelling and the development of pulmonary hypertension (PH) …
pulmonary vascular remodelling and the development of pulmonary hypertension (PH) …
Niclosamide modulates phenotypic switch and inflammatory responses in human pulmonary arterial smooth muscle cells
Y Lu, X Liang, J Song, Y Guan, L Yang, R Shen… - Molecular and Cellular …, 2024 - Springer
Excessive proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs)
represent key steps of pulmonary vascular remodeling, leading to the development of …
represent key steps of pulmonary vascular remodeling, leading to the development of …
Promising dawn in the management of pulmonary hypertension: The mystery veil of gut microbiota
Y Yang, H Zhang, Y Wang, J Xu, S Shu, P Wang… - iMeta, 2024 - Wiley Online Library
The gut microbiota is a complex community of microorganisms inhabiting the intestinal tract,
which plays a vital role in human health. It is intricately involved in the metabolism, and it …
which plays a vital role in human health. It is intricately involved in the metabolism, and it …
Predominance of M2 macrophages in organized thrombi in chronic thromboembolic pulmonary hypertension patients
T Koudstaal, T van den Bosch, I Bergen… - European journal of …, 2024 - Wiley Online Library
Chronic thromboembolic pulmonary hypertension (CTEPH) is a debilitating disease
characterized by thrombotic occlusion of pulmonary arteries and vasculopathy, leading to …
characterized by thrombotic occlusion of pulmonary arteries and vasculopathy, leading to …
[HTML][HTML] Management of pulmonary arterial hypertension: before, during and after pregnancy
Y Teng, L Zong, J Ding, M Wu, X Li - International Journal of Cardiology …, 2024 - Elsevier
Pregnancy complicated with pulmonary arterial hypertension (PAH) is a severe and
dangerous condition for both the mother and the fetus. Pregnancy-specific alterations in the …
dangerous condition for both the mother and the fetus. Pregnancy-specific alterations in the …