The maintenance of cellular identity requires continuous adaptation to environmental
changes. This process is particularly critical for stem cells, which need to preserve their …

Recently, we showed that generation of tumours in syngeneic mice by cells devoid of
mitochondrial (mt) DNA (ρ0 cells) is linked to the acquisition of the host mtDNA. However …

Background Mitochondrial Lon is a chaperone and DNA-binding protein that functions in
protein quality control and stress response pathways. The level of Lon regulates …

Mitochondria are the major organelles in sensing cellular stress and inducing the response
for cell survival. Mitochondrial Lon has been identified as an important stress protein …

Genetic manipulation of mitochondrial DNA (mtDNA) could be harnessed for deciphering
the gene function of mitochondria; it also acts as a promising approach for the therapeutic …

We generated cattle embryos using mitochondrial supplementation and somatic cell nuclear
transfer (SCNT), named miNT, to determine how additional mitochondrial DNA (mtDNA) …

There are some indications that the prevalence of benign and malign neoplasms is
increased in patients with a mitochondrial disorder (MID). This study aimed at calculating the …

Mitochondria are the major organelles in sensing cellular stress and inducing the response
for cell survival. Mitochondrial Lon has been identified as an important stress protein …

Studies, accumulated over recent years, indicate that mitochondria are, along with the
nucleus, the most important target of radiation damage. The structural and functional …

Накопленные за последние годы результаты исследований указывают, что важнейшей
мишенью радиационного поражения, наряду с ядром, являются митохондрии …