The human ether-a-go-go related gene (hERG) encodes the pore-forming subunit of the
rapid component of the delayed rectifier K+ channel, Kv11. 1, which are expressed in the …

The Cnidaria phylum includes organisms that are among the most venomous animals. The
Anthozoa class includes sea anemones, hard corals, soft corals and sea pens. The …

Sea anemones produce venoms of exceptional molecular diversity, with at least 17 different
molecular scaffolds reported to date. These venom components have traditionally been …

More than a century of research on sea anemone venoms has shown that they contain a
diversity of biologically active proteins and peptides. However, recent omics studies have …

Animal venoms are rich natural sources of bioactive compounds, including peptide toxins
acting on the various types of ion channels, ie K+, Na+, Cl-and Ca2+. Among K+ channel …

Voltage-gated potassium channels play a key role in human physiology and pathology.
Reflecting their importance, numerous channelopathies have been characterised that arise …

Acid-sensing ion channels (ASICs) are voltage-independent H+-gated cation channels
largely expressed in the nervous system of rodents and humans. At least six isoforms …

APETx3, a novel peptide isolated from the sea anemone Anthopleura elegantissima, is a
naturally occurring mutant from APETx1, only differing by a Thr to Pro substitution at position …

Crotamine, a 5-kDa peptide, possesses a unique biological versatility. Not only has its cell-
penetrating activity become of clinical interest but, moreover, its potential selective antitumor …

Sea anemones produce a variety of toxic peptides and proteins, including many ion channel
blockers and modulators, as well as potent cytolysins. This review describes the structures …