It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Ovarian aging in women correlates with the progressive loss of both the number and quality
of oocytes. When these processes occur early or are accelerated, their clinical correlates are …

Reproductive aging in female mammals is an irreversible process associated with declining
oocyte quality, which is the rate-limiting factor to fertility. Here, we show that this loss of …

Reproductive capacity in women starts to decline beyond their mid-30s and pregnancies in
older women result in higher rates of miscarriage with aneuploidy. Age-related decline in …

BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

Objective To determine the clinical value of preimplantation genetic diagnosis for
aneuploidy screening (PGD-A) in women of advanced maternal age (AMA; between 38 and …

STUDY QUESTION How should recurrent implantation failure (RIF) in patients undergoing
ART be defined and managed? SUMMARY ANSWER This is the first ESHRE good practice …

BACKGROUND A normal chromosomal constitution defined through PGT-A assessing all
chromosomes on trophectoderm (TE) biopsies represents the strongest predictor of embryo …

Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Mitochondria, fundamental organelles in cell metabolism, and ATP synthesis are
responsible for generating reactive oxygen species (ROS), calcium homeostasis, and cell …