Both animal models and human observational and genetic studies have shown that immune
and inflammatory mechanisms play a key role in hypertension and its complications. We …

Arachidonic acid is one of the most abundant and ubiquitous ω-6 polyunsaturated fatty acid,
present in esterified form in the membrane phospholipids of all mammalian cells and …

Several decades of research in the area of exercise immunology have shown that the
immune system is highly responsive to acute and chronic exercise training. Moderate …

Vitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to
their biosynthesis. However, our understanding of their independent and co-regulation is …

Cardiovascular disease is the leading global health concern and responsible for more
deaths worldwide than any other type of disorder. Atherosclerosis is a chronic inflammatory …

Lysosomal acid lipase (LAL) is the sole enzyme known to degrade neutral lipids in the
lysosome. Mutations in the LAL-encoding LIPA gene lead to rare lysosomal lipid storage …

Inflammation is a marker of arterial disease stemming from cholesterol-dependent to-
independent molecular mechanisms. In recent years, the role of inflammation in …

Idiopathic pulmonary fibrosis (IPF) is a chronic irreversible interstitial lung disease
characterized by a progressive decline in lung function. The etiology of IPF is unknown …

Aim Loss of immunosuppressive response supports inflammation during atherosclerosis.
We tested whether adoptive cell therapy (ACT) with Tregulatory cells (Tregs), engineered to …

Activation of T cells relies on the availability of intracellular cholesterol for an effective
response after stimulation. We investigated the contribution of cholesterol derived from …