Pancreatic β-cell dysfunction plays an important role in the pathogenesis of both type 1 and
type 2 diabetes. Insulin, which is produced in β-cells, is a critical regulator of metabolism …

Faced with a global epidemic of type 2 diabetes (T2D), it is critical that researchers improve
our understanding of the pathogenesis of T2D and related vascular complications. These …

The genetic architectures of common, complex diseases are largely uncharacterized. We
modeled the genetic architecture underlying genome-wide association study (GWAS) data …

Although it has long been assumed that insulin resistance is the leading factor in the
pathogenesis of type 2 diabetes (1), evidence for the importance of the pancreatic β-cells …

India has rapidly become a “diabetes capital” of the world, despite maintaining high rates of
under-nutrition. Indians develop diabetes at younger age and at lower body weights than …

Background Several studies have shown that weight changes are common in patients with
coeliac disease after starting a gluten‐free diet (GFD), but data on the prevalence of …

Recent studies in both humans and animals suggest that air pollution is an important risk
factor for type 2 diabetes mellitus (T2DM). However, the mechanism by which air pollution …

Mechanisms of glucose homeostasis are remarkably well conserved between the fruit fly
Drosophila melanogaster and mammals. From the initial characterization of insulin signaling …

Context: Polycystic ovary syndrome (PCOS) is a common complex genetic disease. It is
characterized by hyperandrogenism, gonadotropin secretory changes, polycystic ovarian …

This update expands the prior scientific statement on the relevance of genetics and
genomics for the prevention and treatment of CVDs. 2 In the earlier report, we focused on …