Yarrowia lipolytica: Safety assessment of an oleaginous yeast with a great industrial potential

M Groenewald, T Boekhout, C Neuvéglise… - Critical reviews in …, 2014 - Taylor & Francis
Yarrowia lipolytica has been developed as a production host for a large variety of
biotechnological applications. Efficacy and safety studies have demonstrated the safe use of …

Recent advances and perspectives on production of value-added organic acids through metabolic engineering

H Liu, Y Jin, R Zhang, Y Ning, Y Yu, P Xu, L Deng… - Biotechnology …, 2023 - Elsevier
Organic acids are important consumable materials with a wide range of applications in the
food, biopolymer and chemical industries. The global consumer organic acids market is …

Biotechnological applications of Yarrowia lipolytica: past, present and future

HH Liu, XJ Ji, H Huang - Biotechnology Advances, 2015 - Elsevier
Non-conventional yeasts have attracted increasing interest due to their biochemical
characteristics and potential applications. Yarrowia lipolytica is a non-conventional yeast …

Metabolic engineering in the biotechnological production of organic acids in the tricarboxylic acid cycle of microorganisms: advances and prospects

X Yin, J Li, H Shin, G Du, L Liu, J Chen - Biotechnology advances, 2015 - Elsevier
Organic acids, which are chemically synthesized, are also natural intermediates in the
metabolic pathways of microorganisms, among which the tricarboxylic acid (TCA) cycle is …

[HTML][HTML] Yarrowia lipolytica: recent achievements in heterologous protein expression and pathway engineering

C Madzak - Applied microbiology and biotechnology, 2015 - Springer
The oleaginous yeast Yarrowia lipolytica has become a recognized system for
expression/secretion of heterologous proteins. This non-conventional yeast is currently …

Biobased organic acids production by metabolically engineered microorganisms

Y Chen, J Nielsen - Current opinion in biotechnology, 2016 - Elsevier
Highlights•The use of inexpensive carbon sources is urgently needed for citric acid
production.•Low-pH process benefits lactic acid production.•Different strains and processes …

Metabolic engineering for expanding the substrate range of Yarrowia lipolytica

R Ledesma-Amaro, JM Nicaud - Trends in Biotechnology, 2016 - cell.com
Economically viable biotechnology processes must be characterized by a favorable ratio
between the production costs and the product market price. In the bioproduction of bulk …

[HTML][HTML] Citric acid bioproduction and downstream processing: Status, opportunities, and challenges

S Mores, LP de Souza Vandenberghe, AIM Júnior… - Bioresource …, 2021 - Elsevier
Citric acid (CA) has been widely used in different industrial sectors, being produced through
fermentation of low-cost feedstock. The development of downstream processes, easier to …

[HTML][HTML] Systems metabolic engineering for citric acid production by Aspergillus niger in the post-genomic era

Z Tong, X Zheng, Y Tong, YC Shi, J Sun - Microbial cell factories, 2019 - Springer
Citric acid is the world's largest consumed organic acid and is widely used in beverage, food
and pharmaceutical industries. Aspergillus niger is the main industrial workhorse for citric …

[HTML][HTML] Sugar Alcohols and Organic Acids Synthesis in Yarrowia lipolytica: Where Are We?

P Fickers, H Cheng, C Sze Ki Lin - Microorganisms, 2020 - mdpi.com
Sugar alcohols and organic acids that derive from the metabolism of certain microorganisms
have a panoply of applications in agro-food, chemical and pharmaceutical industries. The …