Psoriasis is a recurrent, chronic, immune-mediated, systemic inflammatory disease of the
skin, joints, and other organic systems. After atopic dermatitis, chronic stationary psoriasis is …

Psoriasis is the result of uncontrolled keratinocyte proliferation, and its pathogenesis
involves the dysregulation of the immune system. The interplay among cytokines released …

Importance The clinical benefits of novel treatments for moderate to severe psoriasis are
well established, but wide variations exist in patient response across different therapies. In …

Introduction: Generalized pustular psoriasis (GPP) is a rare, severe relapsing/remitting,
multisystem disease that can be difficult to treat. Recent clinical, histological, and genetic …

Importance The association between psoriasis and risk of cancer remains debatable.
Objective To evaluate the association and risk of cancer in patients with psoriasis or …

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …

The management of psoriasis has evolved considerably over the past 100 years. This has
occurred in parallel with our understanding of the pathogenesis of this common, complex …

The emergence of data from clinical trials of biologics, the approval of new biologics, and
our improved understanding of psoriasis pathogenesis have increased the therapeutic …

Psoriasis is a common chronic inflammatory skin disease associated with several
comorbidities and reduced quality of life. In the past decades, highly effective targeted …

The topical route is the most appropriate route for the targeted delivery of drugs to skin
tissues for the treatment of local skin diseases; however, the stratum corneum (SC), the …