Mycobacterial genomics and structural bioinformatics: opportunities and challenges in drug discovery
Of the more than 190 distinct species of Mycobacterium genus, many are economically and
clinically important pathogens of humans or animals. Among those mycobacteria that infect …
clinically important pathogens of humans or animals. Among those mycobacteria that infect …
[HTML][HTML] In-silico lead druggable compounds identification against SARS COVID-19 main protease target from in-house, chembridge and zinc databases by structure …
Pharmacological strategies to lower the viral load among patients suffering from severe
diseases were researched in great detail during the SARS-CoV-2 outbreak. The viral …
diseases were researched in great detail during the SARS-CoV-2 outbreak. The viral …
[HTML][HTML] Prediction of vaccine candidates against Pseudomonas aeruginosa: An integrated genomics and proteomics approach
Pseudomonas aeruginosa is among top critical nosocomial infectious agents due to its
persistent infections and tendency for acquiring drug resistance mechanisms. To date, there …
persistent infections and tendency for acquiring drug resistance mechanisms. To date, there …
[HTML][HTML] Identification of Putative Vaccine and Drug Targets against the Methicillin-Resistant Staphylococcus aureus by Reverse Vaccinology and Subtractive …
Methicillin-resistant Staphylococcus aureus (MRSA) is an opportunistic pathogen and
responsible for causing life-threatening infections. The emergence of hypervirulent and …
responsible for causing life-threatening infections. The emergence of hypervirulent and …
[HTML][HTML] A journey through the Corynebacterium pseudotuberculosis proteome promotes insights into its functional genome
Background Corynebacterium pseudotuberculosis is a Gram-positive facultative intracellular
pathogen and the etiologic agent of illnesses like caseous lymphadenitis in small ruminants …
pathogen and the etiologic agent of illnesses like caseous lymphadenitis in small ruminants …
[HTML][HTML] Genome-Based Drug Target Identification in Human Pathogen Streptococcus gallolyticus
Streptococcus gallolysticus (Sg) is an opportunistic Gram-positive, non-motile bacterium,
which causes infective endocarditis, an inflammation of the inner lining of the heart. As Sg …
which causes infective endocarditis, an inflammation of the inner lining of the heart. As Sg …
[HTML][HTML] Biochemical composition, morphology and antimicrobial susceptibility pattern of Corynebacterium pseudotuberculosis biofilm
Caseous lymphadenitis (CLA) is a ruminant disease caused by Corynebacterium
pseudotuberculosis, a Gram-positive facultative intracellular pathogen. The present work …
pseudotuberculosis, a Gram-positive facultative intracellular pathogen. The present work …
[HTML][HTML] An In Silico Identification of Common Putative Vaccine Candidates against Treponema pallidum: A Reverse Vaccinology and Subtractive Genomics Based …
Sexually transmitted infections (STIs) are caused by a wide variety of bacteria, viruses, and
parasites that are transmitted from one person to another primarily by vaginal, anal, or oral …
parasites that are transmitted from one person to another primarily by vaginal, anal, or oral …
[HTML][HTML] An integrative in-silico approach for therapeutic target identification in the human pathogen Corynebacterium diphtheriae
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for
diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually …
diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually …
[HTML][HTML] Genomic landscape of the emerging XDR Salmonella Typhi for mining druggable targets clpP, hisH, folP and gpmI and screening of novel TCM inhibitors …
Typhoid fever is transmitted by ingestion of polluted water, contaminated food, and stool of
typhoid-infected individuals, mostly in developing countries with poor hygienic …
typhoid-infected individuals, mostly in developing countries with poor hygienic …