Kidney disease represents a serious global health problem. One of the main concerns is its
late diagnosis, only feasible in a progressed disease state. The lack of a clinical …

Acute kidney injury (AKI) due to renal ischemia reperfusion (IR) is a major clinical problem
without effective therapy and is a significant and frequent cause of morbidity and mortality …

Background How best to characterize intraoperative hypotension remains unclear. Thus, the
authors assessed the relationship between myocardial and kidney injury and intraoperative …

Ischemia/reperfusion injury is an unavoidable relevant consequence after kidney
transplantation and influences short term as well as long-term graft outcome. Clinically …

Multiple large clinical trials have shown that sodium-glucose cotransporter (SGLT) 2
inhibitors reduce the risk of renal events. However, the mechanism responsible for this …

Ischemia–reperfusion (IR) injury to the kidney occurs in a range of clinically important
scenarios including hypotension, sepsis and in surgical procedures such as cardiac bypass …

Tissue hypoxia has been proposed as an important factor in the pathophysiology of both
chronic kidney disease (CKD) and acute kidney injury (AKI), initiating and propagating a …

Abstract Background Mesenchymal stromal cells (MSCs) and renal stem/progenitors
improve the recovery of acute kidney injury (AKI) mainly through the release of paracrine …

Acute kidney injury (AKI) is a major kidney disease featured by a rapid decline of renal
function. Pathologically, AKI is characterized by tubular epithelial cell injury and death …

Ischemia reperfusion injury occurs in the kidney when blood supply is interrupted in clinical
settings such as kidney transplantation or nephron sparing surgery for renal tumors. These …