This is the second of 2 articles that discuss the biology and pathophysiology of wound
healing, reviewing the role that growth factors play in this process and describing the current …

Affinity‐based drug delivery systems utilize interactions between the therapeutic drug and
the delivery system to manipulate drug loading and to control drug release. In this paper …

Electrospun nanofibrous scaffolds show great application potentials for wound healing
owing to their effective simulation of extracellular matrix (ECM). Three-dimensional (3D) …

Tissue engineering is an emerging multidisciplinary field of investigation focused on the
regeneration of diseased or injured tissues through the delivery of appropriate molecular …

Heparin-conjugated electrospun poly (ε-caprolactone)(PCL)/gelatin scaffolds were
developed to provide controlled release of platelet-derived growth factor-BB (PDGF-BB) and …

Controlled long-term release of basic fibroblast growth factor (bFGF) has shown a combined
effect on the stimulation of regenerating a number of tissues including cartilage, nerve, skin …

Slow vascularization rate is considered one of the main drawbacks of scaffolds used in
wound healing. Several efforts, including cellular and acellular technologies, have been …

Regeneration deficiency is one of the main obstacles limiting the effectiveness of tissue-
engineered scaffolds. To develop scaffolds that are capable of accelerating regeneration …

In many diseases, protease expressions are found deregulated when compared with them
at the healthy states. The unique ability to hydrolyze protein amide bonds has made those …

The poor vascularization rate of matrices following cell invasion is considered to be one of
the main shortcomings of scaffolds used in tissue engineering. In the past decade much …