Expression of MMP, HPSE, and FAP in stroma promoted corneal neovascularization induced by different etiological factors
W Shi, J Liu, M Li, H Gao, T Wang - Current Eye Research, 2010 - Taylor & Francis
Purpose: To observe the relationship between the expression of matrix metalloproteinases
(MMP-2, MMP-9), heparanase (HPSE), and fibroblast activation protein (FAP) in stroma and …
(MMP-2, MMP-9), heparanase (HPSE), and fibroblast activation protein (FAP) in stroma and …
[HTML][HTML] The vital role of blood flow-induced proliferation and migration in capillary network formation in a multiscale model of angiogenesis
Sprouting angiogenesis and capillary network formation are tissue scale phenomena. There
are also sub-scale phenomena involved in angiogenesis including at the cellular and …
are also sub-scale phenomena involved in angiogenesis including at the cellular and …
[HTML][HTML] A multi-scale model for determining the effects of pathophysiology and metabolic disorders on tumor growth
MR Nikmaneshi, B Firoozabadi, A Mozafari, LL Munn - Scientific reports, 2020 - nature.com
The search for efficient chemotherapy drugs and other anti-cancer treatments would benefit
from a deeper understanding of the tumor microenvironment (TME) and its role in tumor …
from a deeper understanding of the tumor microenvironment (TME) and its role in tumor …
Adhesion modulates cell morphology and migration within dense fibrous networks
M Moreira-Soares, SP Cunha, JR Bordin… - Journal of Physics …, 2020 - iopscience.iop.org
One of the most fundamental abilities required for the sustainability of complex life forms is
active cell migration, since it is essential in diverse processes from morphogenesis to …
active cell migration, since it is essential in diverse processes from morphogenesis to …
[HTML][HTML] A mathematical model of fibrinogen-mediated erythrocyte–erythrocyte adhesion
Erythrocytes are deformable cells that undergo progressive biophysical and biochemical
changes affecting the normal blood flow. Fibrinogen, one of the most abundant plasma …
changes affecting the normal blood flow. Fibrinogen, one of the most abundant plasma …
[HTML][HTML] Bridging scales: A hybrid model to simulate vascular tumor growth and treatment response
Cancer is a disease driven by random DNA mutations and the interaction of many complex
phenomena. To improve the understanding and ultimately find more effective treatments …
phenomena. To improve the understanding and ultimately find more effective treatments …
[HTML][HTML] Integrative lymph node-mimicking models created with biomaterials and computational tools to study the immune system
The lymph node (LN) is a vital organ of the lymphatic and immune system that enables
timely detection, response, and clearance of harmful substances from the body. Each LN …
timely detection, response, and clearance of harmful substances from the body. Each LN …
[HTML][HTML] A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets
Cell migration, known as an orchestrated movement of cells, is crucially important for wound
healing, tumor growth, immune response as well as other biomedical processes. This paper …
healing, tumor growth, immune response as well as other biomedical processes. This paper …
Computational models for generating microvascular structures: Investigations beyond medical imaging resolution
Angiogenesis, arteriogenesis, and pruning are revascularization processes essential to our
natural vascular development and adaptation, as well as central players in the onset and …
natural vascular development and adaptation, as well as central players in the onset and …
[HTML][HTML] Inverting angiogenesis with interstitial flow and chemokine matrix-binding affinity
The molecular signaling pathways that orchestrate angiogenesis have been widely studied,
but the role of biophysical cues has received less attention. Interstitial flow is unavoidable in …
but the role of biophysical cues has received less attention. Interstitial flow is unavoidable in …