An update on the regulatory mechanisms of NLRP3 inflammasome activation
Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …
Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
Ankylosing spondylitis: an autoimmune or autoinflammatory disease?
Ankylosing spondylitis (AS) is a chronic inflammatory disorder of unknown aetiology. Unlike
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
other systemic autoimmune diseases, in AS, the innate immune system has a dominant role …
Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases
Z Szekanecz, IB McInnes, G Schett… - Nature Reviews …, 2021 - nature.com
Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory …
COVID-19 and the clinical course of rheumatic manifestations
The manifestations of COVID-19 have been evolving over time. Various post-COVID-19
syndromes are being recognised. Various viruses have been implicated in the pathogenesis …
syndromes are being recognised. Various viruses have been implicated in the pathogenesis …
Pyroptosis and its role in autoimmune disease: a potential therapeutic target
R You, X He, Z Zeng, Y Zhan, Y Xiao… - Frontiers in …, 2022 - frontiersin.org
Autoimmune diseases are a group of heterogeneous diseases with diverse clinical
manifestations that can be divided into systemic and organ-specific. The common etiology of …
manifestations that can be divided into systemic and organ-specific. The common etiology of …
The role of inflammation in autoimmune disease: a therapeutic target
Y Xiang, M Zhang, D Jiang, Q Su, J Shi - Frontiers in Immunology, 2023 - frontiersin.org
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are
increasing year by year. AIDs are produced by the immune system's misidentification of self …
increasing year by year. AIDs are produced by the immune system's misidentification of self …
Isoliquiritigenin, a potential therapeutic agent for treatment of inflammation-associated diseases
Z Chen, W Ding, X Yang, T Lu, Y Liu - Journal of ethnopharmacology, 2024 - Elsevier
Ethnopharmacological relevance Licorice is a medicinal herb with a 2000-year history of
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …
applications in traditional Chinese medicine. Isoliquiritigenin (ISL) is a bioactive chalcone …
Efficacy and Safety of Mesenchymal Stem Cell Transplantation in the Treatment of Autoimmune Diseases (Rheumatoid Arthritis, Systemic Lupus Erythematosus …
L Zeng, G Yu, K Yang, W Xiang, J Li… - Stem cells …, 2022 - Wiley Online Library
Objective. To evaluate the efficacy and safety of mesenchymal stem cell (MSC)
transplantation in the treatment of autoimmune diseases. Methods. The Chinese and …
transplantation in the treatment of autoimmune diseases. Methods. The Chinese and …
Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity
Neutrophil granulocytes, or neutrophils, are the most abundant circulating leukocytes in
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …
humans and indispensable for antimicrobial immunity, as exemplified in patients with inborn …