The internal circadian clock adapts slowly, if at all, to rapid transitions between different shift
schedules. This leads to misalignment (desynchrony) of rhythmic physiological systems …

The suprachiasmatic nucleus (SCN) controls the circadian rhythm of physiological and
behavioural processes in mammals. Here we show that prokineticin 2 (PK2), a cysteine-rich …

In mammals, the master clock of the suprachiasmatic nuclei (SCN) and subordinate clocks
found throughout the body coordinate circadian rhythms of behavior and physiology. We …

Circadian rhythms influence most of our life activities, notably getting up and going to sleep
every day. The new edition of this book delves into the mechanisms surrounding how these …

Summary microRNAs (miRNAs) are a class of small, noncoding RNAs that regulate the
stability or translation of mRNA transcripts. Although recent work has implicated miRNAs in …

Lithium is commonly used to treat bipolar disorder, which is associated with altered
circadian rhythm. Lithium is a potent inhibitor of glycogen synthase kinase 3 (GSK3), which …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

The circadian system actively synchronizes the temporal sequence of biological functions
with the environment. The oscillatory behavior of the system ensures that entrainment is not …

Cortisol has one of the most distinct and fascinating circadian rhythms in human physiology.
This is regulated by the central clock located in the suprachiasmatic nucleus of the …

The second edition of this best-selling handbook is bigger, more comprehensive, and now
completely current. In addition to thorough updates to the discussions featured in the first …