We use a core molecular model capable of generating circadian rhythms to assess the
robustness of circadian oscillations with respect to molecular noise. The model is based on …

This review consolidates research employing human correlational and experimental work
across brain and body with experimental animal models to provide a more complete …

Melatonin influences insulin secretion both in vivo and in vitro.(i) The effects are MT1‐and
MT2‐receptor‐mediated.(ii) They are specific, high‐affinity, pertussis‐toxin‐sensitive, Gi …

Adaptation to the environment is essential for survival, in all wild animal species seasonal
variation in temperature and food availability needs to be anticipated. This has led to the …

The second edition of this best-selling handbook is bigger, more comprehensive, and now
completely current. In addition to thorough updates to the discussions featured in the first …

For many years, neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus were
thought to contain the unique mammalian clock controlling circadian rhythmicity of …

A role for dopamine (DA) in the regulation of clock genes in the mammalian brain is
suggested by evidence that manipulations of DA receptors can alter the expression of some …

An association with circadian clock function and pathophysiology of aging, major depressive
disorder (MDD), and Alzheimer's disease (AD) is well established and has been proposed …

Circadian rhythm is fundamental in regulating a wide range of cellular, metabolic,
physiological, and behavioral activities in mammals. Although a small number of key …

The evolutionarily ancient methoxyindoleamine, melatonin, has long perplexed investigators
by its versatility of functions and mechanisms of action, which include the regulation of …