Carvedilol attenuates experimentally induced silicosis in rats via modulation of P-AKT/mTOR/TGFβ1 signaling

MG Helal, E Said - International Immunopharmacology, 2019 - Elsevier
Silicosis is a well acknowledged occupational lung disorder with considerable negative
impact on the patients' quality of life. Various signaling pathways have been reported to …

Fraxinellone alleviates kidney fibrosis by inhibiting CUG-binding protein 1-mediated fibroblast activation

B Zheng, M Yuan, S Wang, Y Tan, Y Xu, J Ye… - Toxicology and Applied …, 2021 - Elsevier
Abstract Chronic Kidney Disease (CKD) is a serious threat to human health. In addition,
kidney fibrosis is a key pathogenic intermediate for the progression of CDK. Moreover …

Application of mesenchymal stem cell exosomes in the treatment of skin wounds

X Zhao, W Zhang, J Fan, X Chen, X Wang - Smart Materials in Medicine, 2023 - Elsevier
Mesenchymal stem cell exosomes (MSC-Exos) are a type of cell vesicle with biological
function secreted by mesenchymal stem cells (MSCs). In tissue repair, MSC-Exos are more …

P311 promotes lung fibrosis via stimulation of transforming growth factor-β1,-β2, and-β3 translation

FF Duan, G Barron, A Meliton, GM Mutlu… - American Journal of …, 2019 - atsjournals.org
Interstitial lung fibrosis, a frequently idiopathic and fatal disease, has been linked to the
increased expression of profibrotic transforming growth factor (TGF)-βs. P311 is an RNA …

COVID-19 and interstitial lung diseases: A multifaceted look at the relationship between the two diseases

J Fukihara, Y Kondoh - Respiratory Investigation, 2023 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it has been a fatal …

GED-0507 attenuates lung fibrosis by counteracting myofibroblast transdifferentiation in vivo and in vitro

S Speca, C Dubuquoy, C Rousseaux, P Chavatte… - PloS one, 2021 - journals.plos.org
The development of more effective, better tolerated drug treatments for progressive
pulmonary fibrosis (of which idiopathic pulmonary fibrosis is the most common and severe …

Fibrotic expression profile analysis reveals repurposed drugs with potential anti-fibrotic mode of action

E Karatzas, AC Kakouri, G Kolios, A Delis, GM Spyrou - Plos one, 2021 - journals.plos.org
Fibrotic diseases cover a spectrum of systemic and organ-specific maladies that affect a
large portion of the population, currently without cure. The shared characteristic these …

Artesunate Exerts Organ-and Tissue-Protective Effects by Regulating Oxidative Stress, Inflammation, Autophagy, Apoptosis, and Fibrosis: A Review of Evidence and …

M Zhu, Y Wang, J Han, Y Sun, S Wang, B Yang… - Antioxidants, 2024 - mdpi.com
The human body comprises numerous organs and tissues operating in synchrony, it
facilitates metabolism, circulation, and overall organismal function. Consequently, the well …

[HTML][HTML] An experimental model of the epithelial to mesenchymal transition and pro-fibrogenesis in urothelial cells related to bladder pain syndrome/interstitial cystitis

XW Jin, QZ Wang, Y Zhao, BK Liu, X Zhang… - Translational …, 2021 - ncbi.nlm.nih.gov
Background Suitable in vitro models are needed to investigate urothelial epithelial to
mesenchymal transition (EMT) and pro-fibrogenesis phenotype in bladder pain …

Targeting the immune-privileged myofibroblast in oral submucous fibrosis by CAR T-cell therapy

SC Sarode, NK Sharma, G Sarode, M Sharma… - Medical …, 2022 - Elsevier
Despite several advancements in understanding the pathogenesis of oral submucous
fibrosis (OSMF), there is no definitive therapy for the complete remission of the disease …