[HTML][HTML] The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective

C Casalou, A Ferreira, DC Barral - Frontiers in cell and …, 2020 - frontiersin.org
The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …

[HTML][HTML] Membrane trafficking alterations in breast cancer progression

A Ferreira, P Castanheira, C Escrevente… - Frontiers in Cell and …, 2024 - frontiersin.org
Breast cancer (BC) is the most common type of cancer in women, and remains one of the
major causes of death in women worldwide. It is now well established that alterations in …

[HTML][HTML] Explainable drug sensitivity prediction through cancer pathway enrichment

YC Tang, A Gottlieb - Scientific reports, 2021 - nature.com
Computational approaches to predict drug sensitivity can promote precision anticancer
therapeutics. Generalizable and explainable models are of critical importance for translation …

[HTML][HTML] EZH2-Mediated microRNA-375 Upregulation Promotes Progression of Breast Cancer via the Inhibition of FOXO1 and the p53 Signaling Pathway

X Guan, A Shi, Y Zou, M Sun, Y Zhan, Y Dong… - Frontiers in …, 2021 - frontiersin.org
Breast cancer (BC) is the most common gynecologic tumor worldwide where aberrant
expression of microRNAs (miRNAs) is frequently involved. Here, we evaluated the function …

[HTML][HTML] Unraveling the relevance of ARL GTpases in cutaneous melanoma prognosis through integrated bioinformatics analysis

C Brito, B Costa-Silva, DC Barral, M Pojo - International journal of …, 2021 - mdpi.com
Cutaneous melanoma (CM) is the deadliest skin cancer, whose molecular pathways
underlying its malignancy remain unclear. Therefore, new information to guide evidence …

ARF3 inhibits proliferation and promotes apoptosis in gastric cancer by regulating AKT and ERK pathway

J Liu, S Liu, M Wu, J Deng, X Yao, F Liu… - Acta biochimica …, 2021 - abp.ptbioch.edu.pl
Abstract ADP-ribosylation factor 3 (ARF3) has confirmed participate in diverse biological
processes in many cancers. However, the expression patterns and roles of ARF3 in gastric …

Golgi localized Arl15 regulates cargo transport, cell adhesion and motility

P Sharma, PH Venkatesh, N Paddillaya, N Shah… - bioRxiv, 2022 - biorxiv.org
Abstract Arf-like GTPases (Arls) regulate membrane trafficking and cytoskeletal organization.
Genetic studies predicted a role for Arl15 in type-2 diabetes, insulin resistance, adiposity …

Association of ADP‑ribosylation factor family genes with prognosis and immune infiltration of breast cancer

L Yang, S Zhang, L Zheng, F Kong… - Oncology …, 2024 - spandidos-publications.com
Breast cancer (BC) is the most common type of cancer found in women. ADP‑ribosylation
factors (ARFs) are a group of small proteins that bind to GTP and are involved in controlling …

PathDSP: explainable drug sensitivity prediction through cancer pathway enrichment

YC Tang, A Gottlieb - bioRxiv, 2020 - biorxiv.org
Computational approaches to predict drug sensitivity can promote precision anticancer
therapeutics. Generalizable and explainable models are of critical importance for translation …

The small GTPase ARF3 controls metastasis and invasion modality by regulating N-cadherin levels

E Sandilands, EC Freckmann, A Román-Fernández… - bioRxiv, 2022 - biorxiv.org
ARF GTPases are central regulators of membrane trafficking that act by controlling local
membrane identity and remodelling to facilitate vesicle formation. Unravelling ARF GTPase …