Systemic amyloidosis is a relatively rare multisystem disease caused by the deposition of
misfolded protein in various tissues and organs. It may present to almost any specialty, and …

The systemic amyloidoses are a broad spectrum of diseases that result from misfolding of
proteins that aggregate into b-sheet amyloid fibrils. Over 35 amyloidogenic precursor …

Protein misfolding and aggregation has been related to several human disorders, generally
termed protein aggregation diseases. These diseases include neurodegenerative disorders …

[CQ1] What is the role of 99 mTc-PYP scintigraphy (bone scintigraphy) in clinical practice for
CA?∙∙∙∙∙∙ 1655 [CQ2] The role of endomyocardial biopsy. Which site is appropriate for biopsy …

The article looks at a guideline for the diagnosis and investigation of amyloid light-chain (AL)
amyloidosis provided by the British National Amyloidosis Centre. Topics discussed include …

The Oxford Handbook of Clinical Haematology continues to provide the essential
knowledge needed in modern clinical practice for the diagnosis and management of …

Mutations in the fibrinogen Aα-chain gene are the most common cause of hereditary renal
amyloidosis in the United Kingdom. Previous reports of fibrinogen Aα-chain amyloidosis …

Purpose Chemotherapy in AL (primary or light chain) amyloidosis is associated with
improved survival, but its effect on renal outcome has not been examined systematically …

Melphalan remains the most widely used agent in preparative regimens for hematopoietic
stem cell transplantation (SCT). From its initial discovery more than 50 years ago, it has …

Vital organ failure remains common in AL amyloidosis. Solid organ transplantation is
contentious because of the multisystem nature of this disease and risk of recurrence in the …