Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Oxidized low‐density lipoprotein (OxLDL) contributes to the atherosclerotic plaque formation
and progression by several mechanisms, including the induction of endothelial cell …

Vascular smooth muscle cells (VSMC s) exhibit phenotypic and functional plasticity in order
to respond to vascular injury. In case of the vessel damage, VSMC s are able to switch from …

PCSK9 degrades low-density lipoprotein cholesterol (LDL) receptors and subsequently
increases serum LDL cholesterol. Clinical trials show that inhibition of PCSK9 efficiently …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

One of the novel interesting topics in the study of cardiovascular disease is the role of the
oxidation system, since inflammation and oxidative stress are known to lead to …

Atherosclerosis remains a major cause of morbidity and mortality worldwide, and a thorough
understanding of the underlying pathophysiological mechanisms is crucial for the …

The founding member of the lipoprotein receptor family, low-density lipoprotein receptor
(LDLR) plays a major role in the atherogenesis through the receptor-mediated endocytosis …

Myeloperoxidase (MPO) belongs to the heme peroxidase family, which includes a set of
enzymes with potent oxidoreductase activity. MPO is considered an important part of the …