Cancer is the second worldwide cause of death, exceeded only by cardiovascular diseases.
It is characterized by uncontrolled cell proliferation and an absence of cell death that, except …

Several scientific and clinical studies have shown an association between chronic alcohol
consumption and the occurrence of cancer in humans. The mechanism for alcohol-induced …

Although targeted therapy is yielding promising results in the treatment of specific cancers,
drug resistance poses a problem. We develop a mathematical framework that can be used …

We posit the following hypothesis: Independently of whether malignant tumors are initiated
by a fundamental reprogramming of gene expression or seeded by stem cells,“waves” of …

A preponderance of evidence suggests humanity is causing a mass extinction event: the
sixth mass extinction since the rise of complex life on Earth. This paper takes this empirical …

Highlights•3D cell systems show high resistance to cytotoxic treatment compared with 2D
models.•Microfluidic systems allow cost-effective analysis of cytotoxic drugs.•Integration of …

Nutrition science is a highly fractionated, contentious field with rapidly changing viewpoints
on both minor and major issues impacting on public health. With an evolutionary perspective …

Radiation-induced genomic instability (RIGI) challenges the long-standing notion that
radiation's effects derive solely from nuclear impact. In RIGI it is the unirradiated progeny that …

One of the main causes of failure in the treatment of cancer is the development of drug
resistance by the cancer cells. Employing multi-drug therapeutic strategies is a promising …

Because neoplasia is a common disease condition throughout the animal kingdom, it is not
surprising that neoplasia is also a common occurrence in fishes, which represent the largest …