Long-term outcome for patients with high-grade osteosarcoma has improved with the
addition of systemic chemotherapy, but subsequent progress has been less marked …

Osteosarcoma (OS) is the most common type of primary bone tumor in children and
adolescents and has been associated with a high degree of malignancy, early metastasis …

Osteosarcoma is the most common malignant bone tumor, currently treated with pre-and
postoperative chemotherapy in association with the surgical removal of the tumor. About 15 …

The bone is a complex connective tissue composed of many different cell types such as
osteoblasts, osteoclasts, chondrocytes, mesenchymal stem/progenitor cells, hematopoietic …

Abstract Purpose: Recombinant Listeria vaccines induce tumor-specific T-cell responses
that eliminate established tumors and prevent metastatic disease in murine cancer models …

Due to the emergence of adjuvant and neoadjuvant chemotherapy, the survival rate has
been greatly improved in osteosarcoma (OS) patients with localized disease. However, this …

The P2X7 receptor, an ATP‐gated ion channel, is critical for cancer cell growth,
invasiveness, and angiogenesis. Previous studies indicate that P2X7 regulates osteoblast …

Abstract microRNAs (miRNA, miR) play an important role in cancer cell growth and
migration; however, the potential roles of miRNAs in osteosarcoma remain largely …

Abstract In the US 5–10% of new pediatric cases of cancer are primary bone tumors. The
most common type of primary malignant bone tumor is osteosarcoma. The intention of the …

It has been difficult to identify the molecular features central to the pathogenesis of
osteosarcoma owing to a lack of understanding of the cell or origin, the absence of …