Lectins: a primer for histochemists and cell biologists

JC Manning, A Romero, FA Habermann… - Histochemistry and cell …, 2017 - Springer
An experimental observation on se lectin g binding partners underlies the introduction of the
term 'lectin'. Agglutination of erythrocytes depending on their blood-group status revealed …

Galectins: their network and roles in immunity/tumor growth control

H Kaltner, S Toegel, GG Caballero, JC Manning… - Histochemistry and cell …, 2017 - Springer
One route of realizing the information of glycans involves endogenous receptors (lectins).
Occurrence at branch ends renders galactosides particularly accessible. Thus, they are …

How galectins have become multifunctional proteins

G García Caballero, H Kaltner, TJ Kutzner, AK Ludwig… - 2020 - digitum.um.es
Having identified glycans of cellular glycoconjugates as versatile molecular messages, their
recognition by sugar receptors (lectins) is a fundamental mechanism within the flow of …

Crystallization of a human galectin-3 variant with two ordered segments in the shortened N-terminal tail

A Flores-Ibarra, S Vértesy, FJ Medrano, HJ Gabius… - Scientific Reports, 2018 - nature.com
Among members of the family of adhesion/growth-regulatory galectins, galectin-3 (Gal-3)
bears a unique modular architecture. A N-terminal tail (NT) consisting of the N-terminal …

Galectin-3 induces a pro-degradative/inflammatory gene signature in human chondrocytes, teaming up with galectin-1 in osteoarthritis pathogenesis

D Weinmann, K Schlangen, S André, S Schmidt… - Scientific Reports, 2016 - nature.com
Inflammatory chemo-and cytokines and matrix-degrading proteases underlie the
progression of osteoarthritis (OA). Aiming to define upstream regulators for these disease …

From glycophenotyping by (plant) lectin histochemistry to defining functionality of glycans by pairing with endogenous lectins

H Kaltner, G García Caballero, AK Ludwig… - Histochemistry and Cell …, 2018 - Springer
About 60 years ago, the efforts to identify blood group-specific haemagglutinins in plant
extracts by broad-scale testing were beginning to make a large panel of these proteins …

Adhesion/growth-regulatory galectins tested in combination: evidence for formation of hybrids as heterodimers

MC Miller, AK Ludwig, K Wichapong… - Biochemical …, 2018 - portlandpress.com
The delineation of the physiological significance of protein (lectin)–glycan recognition and
the structural analysis of individual lectins have directed our attention to studying them in …

A brief history of galectin evolution

J Günther, SP Galuska - Frontiers in Immunology, 2023 - frontiersin.org
Galectins are a family of carbohydrate-binding proteins found in vertebrates in great
abundance and diversity in terms of both structure and ligand-binding properties as well as …

Chicken lens development: complete signature of expression of galectins during embryogenesis and evidence for their complex formation with α-, β-, δ-, and τ …

G García Caballero, S Schmidt, JC Manning… - Cell and tissue …, 2020 - Springer
The emerging multifunctionality of galectins by specific protein-glycan/protein interactions
explains the interest to determine their expression during embryogenesis. Complete network …

Network analysis of adhesion/growth‐regulatory galectins and their binding sites in adult chicken retina and choroid

JC Manning, G García Caballero, C Knospe… - Journal of …, 2017 - Wiley Online Library
The highly ordered multilayered organization of the adult chicken retina is a suitable test
model for examining zonal distribution of the members of a bioeffector family. Based on the …