Although usually benign, anterior pituitary tumours occasionally exhibit aggressive
behaviour, with invasion of surrounding tissues, rapid growth, resistance to conventional …

The WHO categorizes pituitary tumours as typical adenomas, atypical adenomas and
pituitary carcinomas, with typical adenomas constituting the major class. However, the WHO …

Nicotinamide N-methyltransferase (NNMT) is overexpressed in a variety of human cancers,
where it contributes to tumorigenesis by a mechanism that is still poorly understood. Here …

Pituitary adenomas are currently classified by histological, immunocytochemical and
numerous ultrastructural characteristics lacking unequivocal prognostic correlations. We …

The stepwise progression from an early dysplastic lesion to full-blown metastatic malignancy
is associated with increases in genomic instability. Mitotic chromosomal instability—the …

Pituitary adenomas are usually benign monoclonal tumours presenting either due to
hypersecretion of pituitary hormones, and/or due to local space occupying effects and …

Background Dopamine agonist resistance in prolactinoma is an infrequent phenomenon.
Doses of cabergoline (CAB) of up to 2.0 mg/week are usually effective in controlling …

Pituitary adenomas exhibit a wide range of behaviors. The prediction of aggressive or
malignant behavior in pituitary adenomas remains challenging; however, the utility of …

Objective and design A clinicopathological score has been proposed by Trouillas et al. to
predict the evolution of pituitary adenomas. Aim of our study was to perform an independent …

Abstract Context and Objective: Predicting pituitary tumor behavior remains a challenge.
This multiparameter investigation aimed to identify markers for recurrence and progression …