Neuropsychology of multiple sclerosis: looking back and moving forward

RHB Benedict, J DeLuca, C Enzinger… - Journal of the …, 2017 - cambridge.org
The neuropsychological aspects of multiple sclerosis (MS) have evolved over the past three
decades. What was once thought to be a rare occurrence, cognitive dysfunction is now …

[HTML][HTML] Applications of generative adversarial networks in neuroimaging and clinical neuroscience

R Wang, V Bashyam, Z Yang, F Yu, V Tassopoulou… - Neuroimage, 2023 - Elsevier
Generative adversarial networks (GANs) are one powerful type of deep learning models that
have been successfully utilized in numerous fields. They belong to the broader family of …

Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis

L Starost, M Lindner, M Herold, YKT Xu… - Acta …, 2020 - Springer
Multiple sclerosis (MS) is the most frequent demyelinating disease in young adults and
despite significant advances in immunotherapy, disease progression still cannot be …

Quantitative myelin imaging with MRI and PET: an overview of techniques and their validation status

CWJ van der Weijden, E Biondetti, IW Gutmann… - Brain, 2023 - academic.oup.com
Myelin is the protective sheath wrapped around axons, consisting of a phospholipid bilayer
with water between the wraps. The measurement of damage to the myelin sheaths, the …

Chronic demyelination and axonal degeneration in multiple sclerosis: pathogenesis and therapeutic implications

TJ Simkins, GJ Duncan, D Bourdette - Current neurology and …, 2021 - Springer
Abstract Purpose of Review Multiple sclerosis (MS) is the most common demyelinating
disease of the central nervous system (CNS). Inflammatory attacks in MS lead to both …

Impact of age on multiple sclerosis disease activity and progression

B Zeydan, OH Kantarci - Current neurology and neuroscience reports, 2020 - Springer
Abstract Purpose of Review The purpose of this review is to discuss the interaction between
aging, progressive disease course, disability worsening, and treatment strategies in multiple …

Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer disease and multiple sclerosis

JJ Schubert, M Veronese, L Marchitelli… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Cerebrospinal fluid (CSF) plays an important role in solute clearance and maintenance of
brain homeostasis. 11C-Pittsburgh compound B (PiB) PET was recently proposed as a tool …

Central nervous system remyelination: roles of glia and innate immune cells

CS Baaklini, KS Rawji, GJ Duncan, MFS Ho… - Frontiers in Molecular …, 2019 - frontiersin.org
In diseases such as multiple sclerosis (MS), inflammation can injure the myelin sheath that
surrounds axons, a process known as demyelination. The spontaneous regeneration of …

Achievements and obstacles of remyelinating therapies in multiple sclerosis

M Stangel, T Kuhlmann, PM Matthews… - Nature Reviews …, 2017 - nature.com
Remyelination in the CNS is the natural process of damage repair in demyelinating
diseases such as multiple sclerosis (MS). However, remyelination becomes inadequate in …

Progress in understanding the pathophysiology of multiple sclerosis

H Zéphir - Revue neurologique, 2018 - Elsevier
Multiple sclerosis (MS) arises in people who have a genetic susceptibility to environmental
factors and events, which ultimately trigger the disease. It is thought that peripheral immune …