Over the past several decades, the incidence of bacterial meningitis in children has
decreased but there remains a significant burden of disease in adults, with a mortality of up …

Bacterial meningitis is an inflammation of the meninges which covers and protects the brain
and the spinal cord. Such inflammation is mostly caused by blood-borne bacteria that cross …

Background Pneumococcal meningitis is associated with high risk of neurological sequelae
such as cognitive impairment and hearing loss. These sequelae are due to parenchymal …

Escherichia coli is the leading cause of neonatal Gram-negative bacterial meningitis, but the
pathogenesis of E. coli meningitis remains elusive. E. coli penetration of the blood–brain …

Multilocus sequence typing previously identified three predominant sequence types (STs) of
Streptococcus suis serotype 2: ST1 strains predominate in Eurasia while North American …

Central nervous system infections caused by pathogens crossing the blood–brain barrier
are extremely damaging and trigger cellular alterations and neuroinflammation. Bacterial …

Microglia have a pivotal role in the pathophysiology of bacterial meningitis. The goal of this
review is to provide an overview on how microglia respond to bacterial pathogens targeting …

Background Bacterial meningitis (BM) is a serious infectious disease of the central nervous
system that often occurs in children and adolescents. Many studies have suggested that …

Background Despite the effective use of antibiotics, occurrences of mortality and
neurological sequelae following Streptococcus pneumoniae meningitis remain high …

Introduction: Bacterial meningitis (BM) is a medical emergency and its etiology varies
according to the age group and geographic area. Studies have shown that brain damage …