Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Background Neuroinflammation has an important role in the pathophysiology of migraine,
which is a complex neuro-glio-vascular disorder. The main aim of this review is to highlight …

Myelination of axons in the nervous system of vertebrates enables fast, saltatory impulse
propagation, one of the best-understood concepts in neurophysiology. However, it took a …

Genome-wide association studies have identified hundreds of genetic variants associated
with blood pressure (BP), but sequence variation accounts for a small fraction of the …

The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial
cells laid down in regularly spaced segments along axons. Recent studies indicate that …

Myelin membranes are dominated by lipids while the complexity of their protein composition
has long been considered to be low. However, numerous additional myelin proteins have …

The largest pool of free cholesterol in mammals resides in myelin membranes. Myelin
facilitates rapid saltatory impulse propagation by electrical insulation of axons. This function …

The myelination of axons has evolved to enable fast and efficient transduction of electrical
signals in the vertebrate nervous system. Acting as an electric insulator, the myelin sheath is …

Background The discovery of disease-associated loci through genome-wide association
studies (GWAS) is the leading genetic approach to the identification of novel biological …

Extracellular vesicles (EVs) have recently emerged as versatile elements of cell
communication in the nervous system, mediating tissue homeostasis. EVs influence the …