IN RECENT YEARS there has been an explosion of interest in the group of inflammatory
mediators collectively known as cytokines. Research activity in this area is likely to expand …

Vigorous virus-specific CD4+ T-helper-cell responses are associated with successful control
of hepatitis C virus (HCV) and other human viral infections, but the breadth and specificity of …

The factors that determine persistence or clearance of hepatitis C virus (HCV) infection are
poorly understood. The CD4 T cell responses to the HCV core protein were examined in a …

ESOLUTION of acute hepatitis C is generally associ-R ated with detection of neutralizing
antibodies, a high frequency of circulating HCV-specific T cells with a predominant …

Purpose. An imbalance in helper T-cell type 1 (Th1) and type 2 (Th2) cytokines is suggested
to play an important role in the pathogenesis of chronic viral infections, but this issue is not …

Several features of human HCV infection are recapitulated in the chimpanzee model. Most
importantly, the frequency of persistent infection is high in both species, and virus replication …

To compare the functional features of circulating and intrahepatic hepatitis C virus (HCV)-
specific CD4+ T cells in chronic HCV infection, peripheral blood and liver-infiltrating …

Patients coinfected with hepatitis C virus (HCV) and Schistosoma mansoni show high
incidence of viral persistence and accelerated fibrosis. To determine whether immunological …

The present study aimed to examine the effect of astilbin, a flavanoid, on liver injury. When
administered during the effector but not induction phase, astilbin significantly decreased the …

Objective To characterize immune phenotype and function in hepatitis C virus (HCV)
infection in the presence and absence of HIV-1 infection. Design Cross-sectional …