P38α (which is also named MAPK14) plays a pivotal role in initiating different disease states
such as inflammatory disorders, neurodegenerative diseases, cardiovascular cases, and …

Kinases are an intensively studied drug target class in current pharmacological research as
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …

Inflammation is a natural host defense mechanism that protects the body from pathogenic
microorganisms. A growing body of research suggests that inflammation is a key factor in …

The coronavirus, a subfamily of the coronavirinae family, is an RNA virus with over 40
variations that can infect humans, non-human mammals and birds. There are seven types of …

The p38 family is a highly evolutionarily conserved group of mitogen‐activated protein
kinases (MAPKs) that is involved in and helps co‐ordinate cellular responses to nearly all …

Benzodioxane has long been a versatile template widely employed to design molecules
endowed with diverse bioactivities. Its use spans the last decades of medicinal chemistry …

Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Despite the
existence of various therapeutic options, NSCLC is still a major health concern due to its …

The recent increase of bioactivity data freely available to the scientific community and stored
as activity data points in chemogenomic repositories provides a huge amount of ready-to …

There is an urgent need to identify efficient antiviral compounds to combat existing and
emerging RNA virus infections, particularly those related to seasonal and pandemic …

Acute myeloid leukemia (AML) is a heterogeneous hematopoietic malignancy whose
prognosis is globally poor. In more than 60% of AML patients, the PI3K/AKTs/mTOR …