Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Environmental insults impair human health around the world. Contaminated air, water, soil,
food, and occupational and household settings expose humans of all ages to a plethora of …

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

The aging process is accompanied by critical changes in cellular and molecular functions,
which upset the homeostatic balance in the central nervous system. Accumulation of metals …

The pollution of heavy metals (HMs) in the environment is a significant global environmental
issue, characterized by its extensive distribution, severe contamination, and profound …

Metals are ubiquitous chemical entities involved in a myriad of biological processes. Despite
their integral role in sustaining life, overexposure can lead to deleterious neurological …

Exposure of individuals to heavy metals (HMs) is a growing concern with far-reaching
implications for human health. HMs encompass a diverse range of elements that, when …

Heavy metals are ubiquitous in nature and their bioaccumulation usually remains
undetected until it manifests as a chronic pathological condition. Accumulating evidence …

The present study aims to determine the associations of multiple plasma metal levels and
plasma microRNAs (miRNAs) with diabetes risk, and further explore the mediating effects of …

There are several candidate signalling pathways that mediate the response of the central
nervous system (CNS) cells to environmental toxins. However, much is still to be learned on …