Since its first clinical description (on his son) by William James West (1793–1848) in 1841,
and the definition of the classical triad of (1) infantile spasms;(2) hypsarrhythmia, and (3) …

Lennox-Gastaut syndrome (LGS) is considered an epileptic encephalopathy and is defined
by a triad of multiple drug-resistant seizure types, a specific EEG pattern showing bursts of …

Abstract The International League Against Epilepsy (ILAE) Task Force on Nosology and
Definitions proposes a classification and definition of epilepsy syndromes in the neonate …

Background Infantile spasms constitutes a severe infantile epilepsy syndrome that is difficult
to treat and has a high morbidity. Hormonal therapies or vigabatrin are the most commonly …

Autism is more common in people with epilepsy, approximately 20%, and epilepsy is more
common in people with autism with reported rates of approximately 20%. However, these …

The high pace of gene discovery has resulted in thrilling advances in the field of epilepsy
genetics. Clinical testing with comprehensive gene panels, exomes, or genomes are now …

Background Infantile spasms constitute a severe form of epileptic encephalopathy. In the
International Collaborative Infantile Spasms Study (ICISS), we showed that combining …

The association between autism spectrum disorder (ASD) and epilepsy has been described
for decades, and yet we still lack the full understanding of this relationship both clinically and …

OBJECTIVES: Tuberous sclerosis complex (TSC) is a neurocutaneous genetic disorder with
a high prevalence of epilepsy and neurodevelopmental disorders. TSC can be challenging …

The common age-dependent West syndrome can be diagnosed accurately by
electroencephalogram (EEG), but its pathogenesis and evolution remain unclear. Existing …