The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products

JP Shiau, YT Chuang, JY Tang, KH Yang, FR Chang… - Antioxidants, 2022 - mdpi.com
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …

[HTML][HTML] Molecular insights into artemisinin resistance in Plasmodium falciparum: An updated review

WA Azmi, AFM Rizki, Y Djuardi, IM Artika… - Infection, Genetics and …, 2023 - Elsevier
Malaria still poses a major burden on human health around the world, especially in endemic
areas. Plasmodium resistance to several antimalarial drugs has been one of the major …

Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway

G Chen, H Zhang, H Sun, X Ding, G Liu, F Yang… - Apoptosis, 2023 - Springer
Gastric cancer (GC) is the most common malignant tumor of digestive system. Bufalin
extracted from Venenum Bufonis is one of the most effective anticancer monomers, which …

Signaling pathways driving ocular malignancies and their targeting by bioactive phytochemicals

CR Croley, J Pumarol, BE Delgadillo, AC Cook… - Pharmacology & …, 2023 - Elsevier
Ocular cancers represent a rare pathology. The American Cancer Society estimates that
3,360 cases of ocular cancer occur annually in the United States. The major types of cancers …

PI3K/AKT/mTOR pathway-derived risk score exhibits correlation with immune infiltration in uveal melanoma patients

Y Geng, Y Geng, X Liu, Q Chai, X Li, T Ren… - Frontiers in …, 2023 - frontiersin.org
Uveal melanoma (UVM) is a rare but highly aggressive intraocular tumor with a poor
prognosis and limited therapeutic options. Recent studies have implicated the …

FOXD1 expression-based prognostic model for uveal melanoma

Y Luo, R Ni, X Jin, P Feng, C Dai, L Jiang, P Chen… - Heliyon, 2023 - cell.com
FOXD1, a new member of the FOX transcription factor family, serves as a mediator and
biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma …

Next‐generation sequencing of uveal melanoma with clinical and histological correlations: Prognostic value of new mutations in the PI3K/AKT/mTOR pathway

M Pérez‐Pérez, A Agostino… - Clinical & …, 2023 - Wiley Online Library
Background Uveal melanoma (UM) is the eye's most common primary malignancy and there
are no effective therapies for disseminated disease. It is important to try to know the patient's …

Expression and functional significance of phosphoenolpyruvate carboxykinase 1 in uveal melanoma

H Bi, J Zhang, Y Yao, S Wang, J Yao, Z Shao… - Cell Death …, 2024 - nature.com
Uveal melanoma (UVM), an uncommon yet potentially life-threatening ocular cancer, arises
from melanocytes in the uveal tract of the eye. The exploration of novel oncotargets for UVM …

TRPM4 and TRPV2 are two novel prognostic biomarkers and promising targeted therapy in UVM

J Wang, S Qiao, S Liang, C Qian, Y Dong… - Frontiers in Molecular …, 2022 - frontiersin.org
Uveal melanoma (UVM) is the most common primary intraocular malignancy tumor in adults.
Almost 50% of UVM patients develop metastatic disease, and is usually fatal within 1 year …

MITF deficiency and oncogenic GNAQ each promote proliferation programs in zebrafish melanocyte lineage cells

GB Phelps, A Amsterdam, HR Hagen… - Pigment Cell & …, 2022 - Wiley Online Library
Uveal melanoma (UM) is the most common primary malignancy of the adult eye but lacks
any FDA‐approved therapy for the deadly metastatic disease. Thus, there is a great need to …